Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

RESEARCH ARTICLE Open Access Plasticity of DNA methylation in mouse T cell activation and differentiation

Yan Li
Guobing Chen
Lina Ma
Stephen J Ohms
Chao Sun
M Frances Shannon
Jun Y Fan

August 2016

Background: Circulating CD4+ T helper cells are activated through interactions with antigen presenti...

Multi-layered epigenetic control of T cell fate decisions

Yu, Bingfei

January 2018

CD8 + T cells are a central component of the adaptive immune system. Upon infection, a naive CD8 + T...

DNA Methylation and Immune Memory Response

Nathalia Noschang Mittelstaedt
André Luiz Becker
Deise Nascimento de Freitas
Rafael F. Zanin
Renato T. Stein
Ana Paula Duarte de Souza

October 2021

The generation of memory is a cardinal feature of the adaptive immune response, involving different ...

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A..
Ardakani, F.B.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.D.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.S.
Sieverling, L.
Chang, H.D.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.R.
Rosenstiel, P.
Schulz, M.H.
Schultze, J.L.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.K.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A..
Ardakani, F.B.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.D.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.S.
Sieverling, L.
Chang, H.D.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.R.
Rosenstiel, P.
Schulz, M.H.
Schultze, J.L.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.K.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A.
Ardakani, F.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.
Sieverling, L.
Consortium, D.
Chang, H.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.
Rosenstiel, P.
Schulz, M.
Schultze, J.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A.
Ardakani, F.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.
Sieverling, L.
Consortium, D.
Chang, H.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.
Rosenstiel, P.
Schulz, M.
Schultze, J.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, Pawel
Nordström, Karl
Gasparoni, Gilles
Salhab, Abdulrahman
Kressler, Christopher
de Almeida, Melanie
Bassler, Kevin
Ulas, Thomas
Schmidt, Florian
Xiong, Jieyi
Glažar, Petar
Klironomos, Filippos
Sinha, Anupam
Kinkley, Sarah
Yang, Xinyi
Arrigoni, Laura
Amirabad, Azim Dehghani
Ardakani, Fatemeh Behjati
Feuerbach, Lars
Gorka, Oliver
Ebert, Peter
Müller, Fabian
Li, Na
Frischbutter, Stefan
Schlickeiser, Stephan
Cendon, Carla
Fröhler, Sebastian
Felder, Bärbel
Gasparoni, Nina
Imbusch, Charles D.
Hutter, Barbara
Zipprich, Gideon
Tauchmann, Yvonne
Reinke, Simon
Wassilew, Georgi
Hoffmann, Ute
Richter, Andreas S.
Sieverling, Lina
Chang, Hyun-Dong
Syrbe, Uta
Kalus, Ulrich
Eils, Jürgen
Brors, Benedikt
Manke, Thomas
Ruland, Jürgen
Lengauer, Thomas
Rajewsky, Nikolaus
Chen, Wei
Dong, Jun
Sawitzki, Birgit
Chung, Ho-Ryun
Rosenstiel, Philip
Schulz, Marcel H.
Schultze, Joachim L.
Radbruch, Andreas
Walter, Jörn
Hamann, Alf
Polansky, Julia K.

November 2016

SummaryThe impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation.

Russ, BE
Prier, JE
Rao, S
Turner, SJ

January 2013

Cellular differentiation is regulated by the strict spatial and temporal control of gene expression....

Stochastics of Cellular Differentiation Explained by Epigenetics: The Case of T-Cell Differentiation and Functional Plasticity

Bhat, J.
Helmuth, J.
Chitadze, G.
Kouakanou, L.
Peters, C.
Vingron, M.
Ammerpohl, O.
Kabelitz, D.

October 2017

Epigenetic marks including histone modifications and DNA methylation are associated with the regulat...

Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation

J Ramon Tejedor
Clara Bueno
Isabel Cobo
Gustavo F Bayon
Cristina Prieto
Cristina Mangas
Raul F. Pérez
Pablo Santamarina
Rocío G Urdinguio
Pablo Menendez
Mario F Fraga
Agustin F Fernandez

December 2017

Epigenetic regulation plays an important role in cellular development and differentiation. A detaile...

Multi-layered epigenetic control of T cell fate decisions

Yu, Bingfei

January 2018

CD8 + T cells are a central component of the adaptive immune system. Upon infection, a naive CD8 + T...

RESEARCH ARTICLE Open Access Plasticity of DNA methylation in mouse T cell activation and differentiation

Yan Li
Guobing Chen
Lina Ma
Stephen J Ohms
Chao Sun
M Frances Shannon
Jun Y Fan

August 2016

Background: Circulating CD4+ T helper cells are activated through interactions with antigen presenti...

Multi-layered epigenetic control of T cell fate decisions

Yu, Bingfei

January 2018

CD8 + T cells are a central component of the adaptive immune system. Upon infection, a naive CD8 + T...

DNA Methylation and Immune Memory Response

Nathalia Noschang Mittelstaedt
André Luiz Becker
Deise Nascimento de Freitas
Rafael F. Zanin
Renato T. Stein
Ana Paula Duarte de Souza

October 2021

The generation of memory is a cardinal feature of the adaptive immune response, involving different ...

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A..
Ardakani, F.B.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.D.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.S.
Sieverling, L.
Chang, H.D.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.R.
Rosenstiel, P.
Schulz, M.H.
Schultze, J.L.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.K.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A..
Ardakani, F.B.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.D.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.S.
Sieverling, L.
Chang, H.D.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.R.
Rosenstiel, P.
Schulz, M.H.
Schultze, J.L.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.K.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A.
Ardakani, F.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.
Sieverling, L.
Consortium, D.
Chang, H.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.
Rosenstiel, P.
Schulz, M.
Schultze, J.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, P.
Nordström, K.
Gasparoni, G.
Salhab, A.
Kressler, C.
de Almeida, M.
Bassler, K.
Ulas, T.
Schmidt, F.
Xiong, J.
Glažar, P.
Klironomos, F.
Sinha, A.
Kinkley, S.
Yang, X.
Arrigoni, L.
Amirabad, A.
Ardakani, F.
Feuerbach, L.
Gorka, O.
Ebert, P.
Müller, F.
Li, N.
Frischbutter, S.
Schlickeiser, S.
Cendon, C.
Fröhler, S.
Felder, B.
Gasparoni, N.
Imbusch, C.
Hutter, B.
Zipprich, G.
Tauchmann, Y.
Reinke, S.
Wassilew, G.
Hoffmann, U.
Richter, A.
Sieverling, L.
Consortium, D.
Chang, H.
Syrbe, U.
Kalus, U.
Eils, J.
Brors, B.
Manke, T.
Ruland, J.
Lengauer, T.
Rajewsky, N.
Chen, W.
Dong, J.
Sawitzki, B.
Chung, H.
Rosenstiel, P.
Schulz, M.
Schultze, J.
Radbruch, A.
Walter, J.
Hamann, A.
Polansky, J.

November 2016

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We gene...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, Pawel
Nordström, Karl
Gasparoni, Gilles
Salhab, Abdulrahman
Kressler, Christopher
de Almeida, Melanie
Bassler, Kevin
Ulas, Thomas
Schmidt, Florian
Xiong, Jieyi
Glažar, Petar
Klironomos, Filippos
Sinha, Anupam
Kinkley, Sarah
Yang, Xinyi
Arrigoni, Laura
Amirabad, Azim Dehghani
Ardakani, Fatemeh Behjati
Feuerbach, Lars
Gorka, Oliver
Ebert, Peter
Müller, Fabian
Li, Na
Frischbutter, Stefan
Schlickeiser, Stephan
Cendon, Carla
Fröhler, Sebastian
Felder, Bärbel
Gasparoni, Nina
Imbusch, Charles D.
Hutter, Barbara
Zipprich, Gideon
Tauchmann, Yvonne
Reinke, Simon
Wassilew, Georgi
Hoffmann, Ute
Richter, Andreas S.
Sieverling, Lina
Chang, Hyun-Dong
Syrbe, Uta
Kalus, Ulrich
Eils, Jürgen
Brors, Benedikt
Manke, Thomas
Ruland, Jürgen
Lengauer, Thomas
Rajewsky, Nikolaus
Chen, Wei
Dong, Jun
Sawitzki, Birgit
Chung, Ho-Ryun
Rosenstiel, Philip
Schulz, Marcel H.
Schultze, Joachim L.
Radbruch, Andreas
Walter, Jörn
Hamann, Alf
Polansky, Julia K.

November 2016

SummaryThe impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

Dynamic regulation of DNA methylation in human T-cell biology

Lentini, Antonio

January 2019

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a ...

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation.

Russ, BE
Prier, JE
Rao, S
Turner, SJ

January 2013

Cellular differentiation is regulated by the strict spatial and temporal control of gene expression....

Stochastics of Cellular Differentiation Explained by Epigenetics: The Case of T-Cell Differentiation and Functional Plasticity

Bhat, J.
Helmuth, J.
Chitadze, G.
Kouakanou, L.
Peters, C.
Vingron, M.
Ammerpohl, O.
Kabelitz, D.

October 2017

Epigenetic marks including histone modifications and DNA methylation are associated with the regulat...

Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation

J Ramon Tejedor
Clara Bueno
Isabel Cobo
Gustavo F Bayon
Cristina Prieto
Cristina Mangas
Raul F. Pérez
Pablo Santamarina
Rocío G Urdinguio
Pablo Menendez
Mario F Fraga
Agustin F Fernandez

December 2017

Epigenetic regulation plays an important role in cellular development and differentiation. A detaile...

Multi-layered epigenetic control of T cell fate decisions

Yu, Bingfei

January 2018

CD8 + T cells are a central component of the adaptive immune system. Upon infection, a naive CD8 + T...

RESEARCH ARTICLE Open Access Plasticity of DNA methylation in mouse T cell activation and differentiation

Yan Li
Guobing Chen
Lina Ma
Stephen J Ohms
Chao Sun
M Frances Shannon
Jun Y Fan

August 2016

Background: Circulating CD4+ T helper cells are activated through interactions with antigen presenti...

Multi-layered epigenetic control of T cell fate decisions

Yu, Bingfei

January 2018

CD8 + T cells are a central component of the adaptive immune system. Upon infection, a naive CD8 + T...

DNA Methylation and Immune Memory Response

Nathalia Noschang Mittelstaedt
André Luiz Becker
Deise Nascimento de Freitas
Rafael F. Zanin
Renato T. Stein
Ana Paula Duarte de Souza

October 2021

The generation of memory is a cardinal feature of the adaptive immune response, involving different ...

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Abstract

Extracted data

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Abstract

Extracted data

Topics

Related items

Related items

Topics