The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protei...
The glyoxalase system has been studied since 1913. The biochemical function of this enzymatic system...
Methylglyoxal (MG), a highly reactive a-dicarbonyl metabolite of glucose degradation pathways, prote...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
Advances in molecular biology technology have piqued tremendous interest in glycometabolism and bioe...
The formation and accumulation of advanced glycation endproducts (AGEs) are related to diabetes and ...
International audiencePURPOSE: Low molecular weight carbonyl compounds, such as the alpha-ketoaldehy...
The immune system plays an essential role in protecting the body against pathogens. Immune cells are...
Over the years, new research has elucidated the importance of the very fast formation of AGEs by the...
The immune system plays an essential role in protecting the body against pathogens. Immune cells are...
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of...
The posttranslational modification of macromolecules caused by highly reactive and toxic α-dicarbony...
<div><p>Methylglyoxal (MG), a highly reactive α-dicarbonyl metabolite of glucose degradation pathway...
Advanced glycation end products (AGEs) are a group of molecules that are generated through non-enzym...
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protei...
The glyoxalase system has been studied since 1913. The biochemical function of this enzymatic system...
Methylglyoxal (MG), a highly reactive a-dicarbonyl metabolite of glucose degradation pathways, prote...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
Advances in molecular biology technology have piqued tremendous interest in glycometabolism and bioe...
The formation and accumulation of advanced glycation endproducts (AGEs) are related to diabetes and ...
International audiencePURPOSE: Low molecular weight carbonyl compounds, such as the alpha-ketoaldehy...
The immune system plays an essential role in protecting the body against pathogens. Immune cells are...
Over the years, new research has elucidated the importance of the very fast formation of AGEs by the...
The immune system plays an essential role in protecting the body against pathogens. Immune cells are...
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of...
The posttranslational modification of macromolecules caused by highly reactive and toxic α-dicarbony...
<div><p>Methylglyoxal (MG), a highly reactive α-dicarbonyl metabolite of glucose degradation pathway...
Advanced glycation end products (AGEs) are a group of molecules that are generated through non-enzym...
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protei...
The glyoxalase system has been studied since 1913. The biochemical function of this enzymatic system...
Methylglyoxal (MG), a highly reactive a-dicarbonyl metabolite of glucose degradation pathways, prote...
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