AbstractA conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis
AbstractATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of D...
We investigated mitotic delay during replication arrest (the S-M checkpoint) in DT40 B-lymphoma cell...
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to surviv...
Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic ...
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully...
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully...
SummaryCells must accurately replicate and segregate their DNA once per cell cycle in order to succe...
Checkpoints were originally identified as signalling pathways that delay mitosis in response to DNA ...
The G DNA damage checkpoint prevents mitotic entry in the presence of damaged DNA, and thus is essen...
Accurate DNA replication is crucial for the maintenance of genome integrity. To this aim, cells have...
Accurate DNA replication is crucial for the maintenance of genome integrity. To this aim, cells have...
Maintaining genome integrity is an essential requirement for cells and a tightly regulated DNA damag...
Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with pro...
Replication checkpoint signaling initiates when the DNA struc-tures that form at stalled replication...
DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor t...
AbstractATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of D...
We investigated mitotic delay during replication arrest (the S-M checkpoint) in DT40 B-lymphoma cell...
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to surviv...
Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic ...
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully...
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully...
SummaryCells must accurately replicate and segregate their DNA once per cell cycle in order to succe...
Checkpoints were originally identified as signalling pathways that delay mitosis in response to DNA ...
The G DNA damage checkpoint prevents mitotic entry in the presence of damaged DNA, and thus is essen...
Accurate DNA replication is crucial for the maintenance of genome integrity. To this aim, cells have...
Accurate DNA replication is crucial for the maintenance of genome integrity. To this aim, cells have...
Maintaining genome integrity is an essential requirement for cells and a tightly regulated DNA damag...
Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with pro...
Replication checkpoint signaling initiates when the DNA struc-tures that form at stalled replication...
DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor t...
AbstractATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of D...
We investigated mitotic delay during replication arrest (the S-M checkpoint) in DT40 B-lymphoma cell...
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to surviv...
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