Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial injury?BackgroundThe cysteine proteases calpain and caspase-3 are known mediators of cell death. The aim of this study was to assess their contribution to the tissue damage found in experimental uremia.MethodsCalpain and caspase-3 activities were measured in the hearts of rats that were sham-operated (control), sham-operated and spontaneously hypertensive (SHR), and those rendered uremic by 5/6 nephrectomy (uremic). In an in vitro study, heart myoblasts (Girardi) were incubated with human serum from healthy subjects (control serum conditioned media, CSCM) or uremic patients (uremic serum conditioned media, USCM), in the presence and absence of ca...
There is limited evidence that inhibition of the activity of the cytosolic cysteine protease calpain...
Calpains and endoplasmic reticulum (ER) stress have both been implicated in renal cell death followi...
We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative elasti...
Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial inju...
Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous oua...
Background/Aims: Hyperuricemia is associated with an increased risk for multiple cardiovascular dise...
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.BackgroundActivation of the...
Background Activation of the cysteine protease calpain has been implicated in renal ischemia/reperfu...
Calpain activation has been implicated in the development of ischemia-reperfusion (I-R) injury. Here...
Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function.Backgro...
Aims: The aim of this study was to determine whether calpain is involved in Cl- -induced myocardial ...
Background: Diastolic dysfunction occurs in patients with chronic renal failure. Moreover, serum fro...
Calcium activated neutral protease, calpain, is thought to be activated where intracellular calcium...
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing....
Cardiovascular calcification is highly prevalent and associated with increased morbidity in chronic ...
There is limited evidence that inhibition of the activity of the cytosolic cysteine protease calpain...
Calpains and endoplasmic reticulum (ER) stress have both been implicated in renal cell death followi...
We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative elasti...
Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial inju...
Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous oua...
Background/Aims: Hyperuricemia is associated with an increased risk for multiple cardiovascular dise...
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.BackgroundActivation of the...
Background Activation of the cysteine protease calpain has been implicated in renal ischemia/reperfu...
Calpain activation has been implicated in the development of ischemia-reperfusion (I-R) injury. Here...
Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function.Backgro...
Aims: The aim of this study was to determine whether calpain is involved in Cl- -induced myocardial ...
Background: Diastolic dysfunction occurs in patients with chronic renal failure. Moreover, serum fro...
Calcium activated neutral protease, calpain, is thought to be activated where intracellular calcium...
‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing....
Cardiovascular calcification is highly prevalent and associated with increased morbidity in chronic ...
There is limited evidence that inhibition of the activity of the cytosolic cysteine protease calpain...
Calpains and endoplasmic reticulum (ER) stress have both been implicated in renal cell death followi...
We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative elasti...