SummaryThe sequences of some gene regulatory elements diverge considerably, even between closely related species. A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and ‘grammar’ elements that are critical for maintaining functional integrity
<div><p>Evidence is mounting that the evolution of gene expression plays a major role in adaptation ...
Metazoan gene expression is controlled through the action of long stretches of noncoding DNA that co...
SummaryMany developmental genes are controlled by shadow enhancers—pairs of enhancers that drive ove...
SummaryBackgroundEnhancers are genomic cis-regulatory sequences that integrate spatiotemporal signal...
Enhancers, a subclass of cis-regulatory sequences control gene expression and patterning during deve...
Enhancers are regulatory DNA sequences that control gene spatial-temporal patterning based on their ...
Major advances have been made in understanding the evolution of transcriptional regulation using mic...
Metazoan genomes contain tens of thousands of regions for which there has been recent experimental e...
AbstractTranscriptional control in mammals and Drosophila is often mediated by regulatory sequences ...
Summary: Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early ...
Upstream regulatory sequences that control gene expression evolve rapidly, yet the expression patter...
Lack of knowledge about how regulatory regions evolve in relation to their structure–function may li...
Analysis of cis-regulatory enhancers has revealed that they consist of clustered blocks of highly co...
Within the non-coding portions of the genome lie sets of instructions that specify when, where, and ...
Recently evolved enhancers dominate mammalian gene regulatory landscapes. Mostly exapted from ancest...
<div><p>Evidence is mounting that the evolution of gene expression plays a major role in adaptation ...
Metazoan gene expression is controlled through the action of long stretches of noncoding DNA that co...
SummaryMany developmental genes are controlled by shadow enhancers—pairs of enhancers that drive ove...
SummaryBackgroundEnhancers are genomic cis-regulatory sequences that integrate spatiotemporal signal...
Enhancers, a subclass of cis-regulatory sequences control gene expression and patterning during deve...
Enhancers are regulatory DNA sequences that control gene spatial-temporal patterning based on their ...
Major advances have been made in understanding the evolution of transcriptional regulation using mic...
Metazoan genomes contain tens of thousands of regions for which there has been recent experimental e...
AbstractTranscriptional control in mammals and Drosophila is often mediated by regulatory sequences ...
Summary: Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early ...
Upstream regulatory sequences that control gene expression evolve rapidly, yet the expression patter...
Lack of knowledge about how regulatory regions evolve in relation to their structure–function may li...
Analysis of cis-regulatory enhancers has revealed that they consist of clustered blocks of highly co...
Within the non-coding portions of the genome lie sets of instructions that specify when, where, and ...
Recently evolved enhancers dominate mammalian gene regulatory landscapes. Mostly exapted from ancest...
<div><p>Evidence is mounting that the evolution of gene expression plays a major role in adaptation ...
Metazoan gene expression is controlled through the action of long stretches of noncoding DNA that co...
SummaryMany developmental genes are controlled by shadow enhancers—pairs of enhancers that drive ove...
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