AbstractObjective Cartilage is a typical avasclar tissue that exhibits powerful resistance to angiogenesis or vascular invasion. We previously identified a cartilage-specific 25kDa glycosylated protein, chondromodulin-I (ChM-I), as anti-angiogenic factor. Taking advantage of ectopic bone formation and xenograft tumour model by human chondrosarcoma cell line OUMS-27, we examined how ChM-I is involved in switching of angiogenesis in cartilage.Design Gene expression pattern of ChM-I was examined in 4-week-old mice and mouse embryos by northern blot analysis and in situ hybridization. To evaluate the effect of ChM-I on ectopic bone formation, guanidine extracts of demineralized bone matrix were mixed with the ChM-I-bound heparin-Sepharose beads...
Osteoarthritis (OA) is the site of a reactivation of the endochondral ossification process, characte...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...
AbstractObjective Cartilage is a typical avasclar tissue that exhibits powerful resistance to angiog...
ABSTRACT During endochondral bone formation, vascular invasion into cartilage initiates the replacem...
Chondromodulin I (chm-I), a type II transmembrane protein, is highly expressed in the avascular zone...
AbstractChondromodulin-I (ChM-I) was previously identified as an angiogenesis inhibitor in cartilage...
Chondromodulin I (chm-I), a type II transmembrane protein, is highly expressed in the avascular zone...
Chondromodulin-I (ChM-I) is a 20-25 kDa anti-angiogenic glycoprotein in cartilage matrix. In the pre...
Objectives Hypoxia is known to stabilize hypoxia-inducible factor (HIF) and initiate angiogenic sign...
AbstractCartilage is an avascular tissue, and exhibits anti-angiogenic properties. Cartilage extract...
Angiogenesis is required for endochondral ossification during development and fracture healing; howe...
With rising demand for cartilage tissue repair and replacement, the differentiation of mesenchymal s...
The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Arti...
Bone formation by endochondral ossification is traditionally viewed as a process in which only cells...
Osteoarthritis (OA) is the site of a reactivation of the endochondral ossification process, characte...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...
AbstractObjective Cartilage is a typical avasclar tissue that exhibits powerful resistance to angiog...
ABSTRACT During endochondral bone formation, vascular invasion into cartilage initiates the replacem...
Chondromodulin I (chm-I), a type II transmembrane protein, is highly expressed in the avascular zone...
AbstractChondromodulin-I (ChM-I) was previously identified as an angiogenesis inhibitor in cartilage...
Chondromodulin I (chm-I), a type II transmembrane protein, is highly expressed in the avascular zone...
Chondromodulin-I (ChM-I) is a 20-25 kDa anti-angiogenic glycoprotein in cartilage matrix. In the pre...
Objectives Hypoxia is known to stabilize hypoxia-inducible factor (HIF) and initiate angiogenic sign...
AbstractCartilage is an avascular tissue, and exhibits anti-angiogenic properties. Cartilage extract...
Angiogenesis is required for endochondral ossification during development and fracture healing; howe...
With rising demand for cartilage tissue repair and replacement, the differentiation of mesenchymal s...
The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Arti...
Bone formation by endochondral ossification is traditionally viewed as a process in which only cells...
Osteoarthritis (OA) is the site of a reactivation of the endochondral ossification process, characte...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesench...