Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this issue of Immunity, Di Niro et al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and affinity mature outside of GCs
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites, witho...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechani...
Antibody affinity maturation involves selective survival of high affinity B cells and is thought to ...
A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum ...
The seminal discovery by Eisen that antibodies undergo improvements in antigen-binding affinity over...
The adaptive immune system has the extraordinary ability to develop bespoke antibodies against almos...
Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be...
© 2016 Bannard et al.Antibody affinity maturation occurs in germinal centers (GCs) through iterative...
The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora...
Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition ...
Antibody-secreting cell (ASC) differentiation usually follows two routes: the extrafollicular path-w...
Germinal centers (GCs) form in lymph nodes after immunization or infection to facilitate antibody af...
Affinity maturation of humoral responses to T-cell-dependent antigens occurs in germinal centers (GC...
Protective antibody responses to vaccination or infection depend on affinity maturation, a process b...
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites, witho...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechani...
Antibody affinity maturation involves selective survival of high affinity B cells and is thought to ...
A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum ...
The seminal discovery by Eisen that antibodies undergo improvements in antigen-binding affinity over...
The adaptive immune system has the extraordinary ability to develop bespoke antibodies against almos...
Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be...
© 2016 Bannard et al.Antibody affinity maturation occurs in germinal centers (GCs) through iterative...
The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora...
Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition ...
Antibody-secreting cell (ASC) differentiation usually follows two routes: the extrafollicular path-w...
Germinal centers (GCs) form in lymph nodes after immunization or infection to facilitate antibody af...
Affinity maturation of humoral responses to T-cell-dependent antigens occurs in germinal centers (GC...
Protective antibody responses to vaccination or infection depend on affinity maturation, a process b...
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites, witho...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechani...
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