AbstractHIFα prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the α subunit of the hypoxia inducible transcription factor (HIF) under different oxygen levels. PHDs catalyse the conversion of a prolyl residue, molecular oxygen and α-ketoglutarate to hydroxy-prolyl, carbon dioxide and succinate in a reaction dependent on ferrous iron and ascorbate as cofactors. Recently it was shown that pseudo-hypoxia, HIF induction under normoxic conditions, is an important feature of tumours generated as a consequence of inactivation of the mitochondrial tumour suppressor ‘succinate dehydrogenase’ (SDH). Two models have been proposed to describe the link between SDH inhibition and HIF activation. Both models suggest that a...
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) an...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and h...
HlF alpha prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the a s...
AbstractHIFα prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the ...
International audienceThe genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as t...
Cellular response to oxygen depletion is mediated by HIF (hypoxia-inducible factor). HIF is a hetero...
Cells exposed to low-oxygen conditions (hypoxia) alter their metabolism to survive. This response, a...
Hypoxia inducible factors (HIFs) play vital roles in cellular maintenance of oxygen homeostasis. The...
AbstractSeveral mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase ...
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) an...
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF...
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) an...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and h...
HlF alpha prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the a s...
AbstractHIFα prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the ...
International audienceThe genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as t...
Cellular response to oxygen depletion is mediated by HIF (hypoxia-inducible factor). HIF is a hetero...
Cells exposed to low-oxygen conditions (hypoxia) alter their metabolism to survive. This response, a...
Hypoxia inducible factors (HIFs) play vital roles in cellular maintenance of oxygen homeostasis. The...
AbstractSeveral mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase ...
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) an...
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF...
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) an...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and h...