Greater variability in kidney function is associated with an increased risk of death
- Al-Aly, Ziyad
- Balasubramanian, Sumitra
- McDonald, Jay R.
- Scherrer, Jeffrey F.
- O'Hare, Ann M.
DOIAbstract
Intra-individual variability in kidney function is a common phenomenon; however, predictors of kidney function variability and its prognostic significance are not known. To examine this question, we assembled a cohort of 51,304 US veterans with an estimated glomerular filtration rate (eGFR) <60ml/min at the end of the study period and who had at least two eGFR measurements during the previous 3 years. Variability in kidney function was defined for each patient as the coefficient of variation of the regression line fitted to all outpatient measures of eGFR during this time frame. In adjusted analyses, blacks, women, and those with Current Procedural Terminology and ICD-9-CM diagnostic codes for hypertension, diabetes, cardiovascular disease,...
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