SummaryThe Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and postsynaptic translocation induce the synaptic trapping of AMPARs diffusing in the membrane. AMPAR immobilization requires both phosphorylation of the auxiliary subunit Stargazin and its binding to PDZ domain scaffolds. It does not depend on the PDZ binding domain of GluA1 AMPAR subunit nor its phosphorylation at Ser831. Finally, CaMKII-dependent AMPAR immobilization regulates short-term plasticity. Thus, NMDA-dependent Ca2+ ...
SummaryExcitatory glutamatergic synaptic transmission is critically dependent on maintaining an opti...
AbstractSynaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA...
SummaryAccumulation of AMPA receptors at synapses is a fundamental feature of glutamatergic synaptic...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
Some forms of activity-dependent synaptic potentiation require the activation of postsynaptic Ca2/ca...
AbstractThe synapse contains densely localized and interacting proteins that enable it to adapt to c...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
Calmodulin-dependent kinase II (CaMKII) is key for long-term potentiation of synaptic AMPA receptors...
AbstractSynaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA...
To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino...
SummaryExcitatory glutamatergic synaptic transmission is critically dependent on maintaining an opti...
AbstractSynaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA...
SummaryAccumulation of AMPA receptors at synapses is a fundamental feature of glutamatergic synaptic...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic rec...
Some forms of activity-dependent synaptic potentiation require the activation of postsynaptic Ca2/ca...
AbstractThe synapse contains densely localized and interacting proteins that enable it to adapt to c...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
International audienceThe synapse contains densely localized and interacting proteins that enable it...
Calmodulin-dependent kinase II (CaMKII) is key for long-term potentiation of synaptic AMPA receptors...
AbstractSynaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA...
To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino...
SummaryExcitatory glutamatergic synaptic transmission is critically dependent on maintaining an opti...
AbstractSynaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA...
SummaryAccumulation of AMPA receptors at synapses is a fundamental feature of glutamatergic synaptic...