Mutations disrupting primary cilia cause retinal, renal, and cerebellar defects, and misregulated Sonic hedgehog signaling. A new mouse mutant in the TTBK2 kinase fails to make cilia, and shows neural tube and Sonic hedgehog signaling defects. Ciliary targeting mutations in human TTBK2 are linked to spinocerebellar ataxia, suggesting cilia protect from neurodegeneration
AbstractCilia are dynamic organelles that are essential for a vast array of developmental patterning...
Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harbor...
In this dissertation, I describe the regulation of signal transduction by primary cilia, microtubule...
Mutations disrupting primary cilia cause retinal, renal, and cerebellar defects, and misregulated So...
Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by...
Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by...
SummaryThe primary cilium has critical roles in human development and disease, but the mechanisms th...
AbstractOrganizing centers in the developing brain provide an assortment of instructive patterning c...
Cilia are architecturally complex organelles that protrude from the cell membrane and have signallin...
Abstract Primary cilia are key regulators of embryo development and tissue homeostasis. However, the...
Cilia are architecturally complex organelles that protrude from the cell membrane and have signallin...
Recent recognition of the key role of primary cilia in orchestrating human development and of the di...
Abstract Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders...
Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differ...
(A-D) Representative images of MEFs taken from the embryos of the indicated and serum starved for 48...
AbstractCilia are dynamic organelles that are essential for a vast array of developmental patterning...
Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harbor...
In this dissertation, I describe the regulation of signal transduction by primary cilia, microtubule...
Mutations disrupting primary cilia cause retinal, renal, and cerebellar defects, and misregulated So...
Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by...
Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by...
SummaryThe primary cilium has critical roles in human development and disease, but the mechanisms th...
AbstractOrganizing centers in the developing brain provide an assortment of instructive patterning c...
Cilia are architecturally complex organelles that protrude from the cell membrane and have signallin...
Abstract Primary cilia are key regulators of embryo development and tissue homeostasis. However, the...
Cilia are architecturally complex organelles that protrude from the cell membrane and have signallin...
Recent recognition of the key role of primary cilia in orchestrating human development and of the di...
Abstract Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders...
Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differ...
(A-D) Representative images of MEFs taken from the embryos of the indicated and serum starved for 48...
AbstractCilia are dynamic organelles that are essential for a vast array of developmental patterning...
Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harbor...
In this dissertation, I describe the regulation of signal transduction by primary cilia, microtubule...
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