Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled splicing of constitutive introns but finding off-site and delayed splicing of alternative introns. The results raise the question of whether kinetics distinguishes constitutive from regulated splicing
International audienceIntrons represent almost half of the human genome, yet their vast majority is ...
In eukaryotic cells, the coding exons in a freshly tran-scribed precursor messenger RNA (pre-mRNA) a...
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reactio...
Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reporte...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
Alternative splicing accounts for much of the complexity in higher eukaryotes. Thus, its regulation ...
SummaryRemoval of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile mean...
One of the main challenges in modern biology is understanding how and when genes are turned on. As o...
© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commo...
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairin...
Eukaryotic gene expression is coordinated through a series of processes from which RNA is transcribe...
The discovery that many intron-containing genes can be cotranscriptionally spliced has led to an inc...
Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is...
In eukaryotes the coding regions of most genes are interrupted by introns that must be removed by sp...
Most eukaryotic genes contain introns that interrupt the continuity of the genetic information. Intr...
International audienceIntrons represent almost half of the human genome, yet their vast majority is ...
In eukaryotic cells, the coding exons in a freshly tran-scribed precursor messenger RNA (pre-mRNA) a...
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reactio...
Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reporte...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
Alternative splicing accounts for much of the complexity in higher eukaryotes. Thus, its regulation ...
SummaryRemoval of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile mean...
One of the main challenges in modern biology is understanding how and when genes are turned on. As o...
© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commo...
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairin...
Eukaryotic gene expression is coordinated through a series of processes from which RNA is transcribe...
The discovery that many intron-containing genes can be cotranscriptionally spliced has led to an inc...
Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is...
In eukaryotes the coding regions of most genes are interrupted by introns that must be removed by sp...
Most eukaryotic genes contain introns that interrupt the continuity of the genetic information. Intr...
International audienceIntrons represent almost half of the human genome, yet their vast majority is ...
In eukaryotic cells, the coding exons in a freshly tran-scribed precursor messenger RNA (pre-mRNA) a...
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reactio...
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