The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging
- Muller, Guilherme Cerutti
- Gottlieb, Maria Gabriela Valle
- Luz Correa, Bruna
- Filho, Irênio Gomes
- Moresco, Rafael Noal
- Bauer, Moisés Evandro
DOIAbstract
AbstractAging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negat...
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