Ethylacetate extract of red onion (Allium cepa L.) tunic affects hemodynamic parameters in rats
- Olayeriju, Olanrewaju Sam
- Olaleye, Mary Tolulope
- Crown, Olamide Olajusi
- Komolafe, Kayode
- Boligon, Aline Augusti
- Athayde, Margareth Linde
- Akindahunsi, Akintunde Afolabi
DOIAbstract
AbstractThe effects of ethylacetate extract of red onion (Allium cepa) tunic (ACTE) on some hemodynamic and biochemical parameters were evaluated in normotensive albino rats. Blood pressure parameters were determined in anaesthetized rats orally administered ACTE (10-, 20-, or 40mg/kg) or ramipril (1mg/kg) once daily for 14 days. Respectively, 10-, 20-, or 40mg/kg ACTE produced significant (P<0.01), dose-dependent fall in systolic blood pressure, SBP (21%, 27%, 33%), diastolic blood pressure, DBP (6%, 10%, 16%), pulse pressure, PP (42%, 49%, 56%), mean arterial blood pressure, MAPB (13%, 18%, 23%) and heart rate, HR (4%, 5%, 7%). The highest effective dose (40mg/kg) compared well with ramipril (1mg/kg) with regards to SBP (41%), DBP (19%), ...
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