Among its multiple functions, p53 is a critical regulator of TGF-β responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-β target genes that promote mesoderm specification
A fundamental function of the tumor suppressors p53 and TGFβ is protection of cells against cellular...
SummaryTGF-β signaling is essential for development and proliferative homeostasis. During embryogene...
Abstractp63, a homolog of the tumor suppressor p53, is critical for the development and maintenance ...
Among its multiple functions, p53 is a critical regulator of TGF-β responses. Sasai et al. (2008) no...
SummaryDuring gastrulation of the amphibian embryo, specification of the three germ layers, endo-, e...
The p53 tumor suppressor belongs to a family of proteins that sense multiple cellular inputs to regu...
AbstractRecent work in Xenopus embryos reveals an unexpected developmental role for the tumor suppre...
p53 is a protein with many talents. One of the most fundamental is the ability to act as essential g...
AbstractThe p53 tumor suppressor belongs to a family of proteins that sense multiple cellular inputs...
The p53 tumor suppressor is the focus of intense investigation. It is considered a latent transcript...
Transforming growth factory beta (TGF-beta) is a potent growth inhibitor of epithelial cells. One of...
International audienceEmbryonic stem cells (ESCs) differentiate in vivo and in vitro into all cell l...
Cellular stress results in profound changes in RNA and protein synthesis. How cells integrate this i...
<p>Each genetic alteration would lead to specific changes in gene expression but changes mediated by...
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect...
A fundamental function of the tumor suppressors p53 and TGFβ is protection of cells against cellular...
SummaryTGF-β signaling is essential for development and proliferative homeostasis. During embryogene...
Abstractp63, a homolog of the tumor suppressor p53, is critical for the development and maintenance ...
Among its multiple functions, p53 is a critical regulator of TGF-β responses. Sasai et al. (2008) no...
SummaryDuring gastrulation of the amphibian embryo, specification of the three germ layers, endo-, e...
The p53 tumor suppressor belongs to a family of proteins that sense multiple cellular inputs to regu...
AbstractRecent work in Xenopus embryos reveals an unexpected developmental role for the tumor suppre...
p53 is a protein with many talents. One of the most fundamental is the ability to act as essential g...
AbstractThe p53 tumor suppressor belongs to a family of proteins that sense multiple cellular inputs...
The p53 tumor suppressor is the focus of intense investigation. It is considered a latent transcript...
Transforming growth factory beta (TGF-beta) is a potent growth inhibitor of epithelial cells. One of...
International audienceEmbryonic stem cells (ESCs) differentiate in vivo and in vitro into all cell l...
Cellular stress results in profound changes in RNA and protein synthesis. How cells integrate this i...
<p>Each genetic alteration would lead to specific changes in gene expression but changes mediated by...
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect...
A fundamental function of the tumor suppressors p53 and TGFβ is protection of cells against cellular...
SummaryTGF-β signaling is essential for development and proliferative homeostasis. During embryogene...
Abstractp63, a homolog of the tumor suppressor p53, is critical for the development and maintenance ...
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