RETRACTED: γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo

This article has been retracted at the request of the Authors. Please see http://www.elsevier.com/locate/withdrawalpolicy.Reason: We wish to retract the above paper describing experiments aimed at elucidating how components of the gamma-secretase complex modulate signaling pathways influencing tau phosphorylation and neurodegeneration associated with Alzheimer's Disease. After publication it was brought to our attention that there are serious irregularities in several figures of the paper and based on an analysis of the primary data, we acknowledge that the major conclusions of the paper cannot be supported by some of the figures that were provided for peer review and subsequently published in the final version of the paper. Because the figures in question are essential to support the major conclusions of the paper, we feel that the most appropriate course of action at this time is to retract the paper in its entirety in order to avoid misleading investigators in the field and other readers. The figures were prepared by L.D., and F.F. regrets issues regarding supervision that permitted these errors. The corresponding authors of the paper, F.F., M.E.F, and C.G.D, deeply regret that they did not detect these irregularities prior to publication. While all authors of the paper concur that the paper should be retracted, F.F., C.G.D., L.D., M.P., J.A., and C.G.D., stand by the conclusions of the paper, while M.E.F., R.K., and G.R.J. are supportive of this stance pending replication of the data in question All authors wish to emphasize that the integrity of genetic mutants, transgenic expression lines, and antibody reagents provided or newly generated for this study are not in question. In accordance with these views, the conclusions of this study will be verified and resubmitted for peer review at a future date. We apologize for any inconvenience or misunderstanding that this may have caused our colleagues.On behalf of all co-authors, Carlos G. Dotti, Fabian Feiguin, and Mark E. Fortin