The role of cathepsin B, a lysosomal protease implicated in amyloid-β (Aβ1-42) metabolism, in Alzheimer's disease remains controversial. In this issue of Neuron, Mueller-Steiner et al. manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid, while inactivation accelerates β-amyloidosis
Cathepsins (CTS) are acid lysosomal proteases classified by their structure and catalytic mechanisms...
International audienceAlthough several ADAMs (A disintegrin-like and metalloproteases) have been sho...
BackgroundAlzheimer's disease (AD) is the most frequent and costly neurodegenerative disorder. Altho...
The role of cathepsin B, a lysosomal protease implicated in amyloid-β (Aβ1-42) metabolism, in Alzhei...
Accumulation of amyloid-beta (A beta), believed to be a key trigger of Alzheimer disease (AD), could...
SummaryAlzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the b...
SummaryImpaired degradation of amyloid beta (Aβ) peptides could lead to Aβ accumulation, an early tr...
Alzheimer’s disease (AD) is a severe neurodegenerative disease that is becoming one of the major cau...
Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolyt...
Impaired degradation of amyloid beta (A beta) peptides could lead to A beta accumulation, an early t...
In cerebral amyloidoses, such as Alzheimer's disease, proteolytic processing of the precursor protei...
Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD) appears to be of p...
Alzheimer’s disease (AD) is an age-related neurodegenerative pathology in which defects in proteolyt...
AbstractConverging evidence suggests that the accumulation of cerebral amyloid β-protein (Aβ) in Alz...
Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder and has been rec...
Cathepsins (CTS) are acid lysosomal proteases classified by their structure and catalytic mechanisms...
International audienceAlthough several ADAMs (A disintegrin-like and metalloproteases) have been sho...
BackgroundAlzheimer's disease (AD) is the most frequent and costly neurodegenerative disorder. Altho...
The role of cathepsin B, a lysosomal protease implicated in amyloid-β (Aβ1-42) metabolism, in Alzhei...
Accumulation of amyloid-beta (A beta), believed to be a key trigger of Alzheimer disease (AD), could...
SummaryAlzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the b...
SummaryImpaired degradation of amyloid beta (Aβ) peptides could lead to Aβ accumulation, an early tr...
Alzheimer’s disease (AD) is a severe neurodegenerative disease that is becoming one of the major cau...
Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolyt...
Impaired degradation of amyloid beta (A beta) peptides could lead to A beta accumulation, an early t...
In cerebral amyloidoses, such as Alzheimer's disease, proteolytic processing of the precursor protei...
Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD) appears to be of p...
Alzheimer’s disease (AD) is an age-related neurodegenerative pathology in which defects in proteolyt...
AbstractConverging evidence suggests that the accumulation of cerebral amyloid β-protein (Aβ) in Alz...
Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder and has been rec...
Cathepsins (CTS) are acid lysosomal proteases classified by their structure and catalytic mechanisms...
International audienceAlthough several ADAMs (A disintegrin-like and metalloproteases) have been sho...
BackgroundAlzheimer's disease (AD) is the most frequent and costly neurodegenerative disorder. Altho...
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