Two recent Cancer Cell articles report the discovery of reciprocal feedback regulation between androgenic and PTEN loss/PI3K-AKT signaling in prostate cancer. Both studies link endocrine regulation with a common oncogenic pathway, which led to the development of a combination therapeutic approach with immediate application in prostate cancer
Androgen action in prostate and prostate cancer cells is dependent upon the androgen receptor (AR) p...
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of...
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy and the second leadi...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
The reduction in androgen synthesis and the blockade of the androgen receptor (AR) function by chemi...
Co‐targeting strategies strive to improve cancer outcomes by combining therapies under contextualize...
As the most frequently diagnosed cancer in North American men, prostate cancer can progress to the a...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Prostate cancer is an ideal target for chemoprevention. To date, chemoprevention clinical trials wit...
The progression to castration-resistant prostate cancer (CRPC) correlates with gain-of-function of t...
Androgen ablation is the standard treatment for advanced disease. Despite initial success, approxima...
Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at ea...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
Prostate cancer (PC) is one of the most common causes of death from malignant neoplasms in men in ma...
SummaryIn PTEN-mutated tumors, we show that PI3Kα activity is suppressed and PI3K signaling is drive...
Androgen action in prostate and prostate cancer cells is dependent upon the androgen receptor (AR) p...
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of...
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy and the second leadi...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
The reduction in androgen synthesis and the blockade of the androgen receptor (AR) function by chemi...
Co‐targeting strategies strive to improve cancer outcomes by combining therapies under contextualize...
As the most frequently diagnosed cancer in North American men, prostate cancer can progress to the a...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Prostate cancer is an ideal target for chemoprevention. To date, chemoprevention clinical trials wit...
The progression to castration-resistant prostate cancer (CRPC) correlates with gain-of-function of t...
Androgen ablation is the standard treatment for advanced disease. Despite initial success, approxima...
Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at ea...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
Prostate cancer (PC) is one of the most common causes of death from malignant neoplasms in men in ma...
SummaryIn PTEN-mutated tumors, we show that PI3Kα activity is suppressed and PI3K signaling is drive...
Androgen action in prostate and prostate cancer cells is dependent upon the androgen receptor (AR) p...
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of...
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy and the second leadi...
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