AbstractBackground: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent kinases (CDKs) before mammalian cells can enter the S phase of the cell cycle. As protein phosphatase 1 (PP1) activates Rb and is itself a target for inhibitory phosphorylation by CDKs in vitro, we asked whether any effects of PP1 on cell cycle progression depend on its phosphorylation and are mediated through Rb.Results: Using electrotransfer of recombinant protein into Rb-positive and Rb-negative cells, we have compared the effects of a wild-type PP1 catalytic subunit, PP1α, and a constitutively active mutant of this subunit (PP1αT320A) on G1 progression, proliferation rates, and cell viability. In treated cells, PP1α levels were elevated 6–...
Background: The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein P...
The ability to regulate cell cycle progression is one of the differences that separates normal from ...
The retinoblastoma tumor suppressor protein (RB) is activated/dephosphorylated to mediate cell cycle...
AbstractBackground: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent k...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
The family of Retinoblastoma/pocket proteins is one of the master regulators of the eukaryotic cell ...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobl...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. Howev...
The prevailing model of G1 cell cycle progression proposes Cyclin D:Cyclin-dependent kinase 4/6 (Cdk...
The antiproliferative action of the retinoblastoma tumor suppressor protein, RB, is disrupted in the...
It is becoming evident that defective cell cycle regulation is an important property of the cancer c...
It is widely accepted that phosphorylation of the retinoblastoma (Rb) protein during the G1 phase of...
Background: The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein P...
The ability to regulate cell cycle progression is one of the differences that separates normal from ...
The retinoblastoma tumor suppressor protein (RB) is activated/dephosphorylated to mediate cell cycle...
AbstractBackground: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent k...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
The family of Retinoblastoma/pocket proteins is one of the master regulators of the eukaryotic cell ...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobl...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. Howev...
The prevailing model of G1 cell cycle progression proposes Cyclin D:Cyclin-dependent kinase 4/6 (Cdk...
The antiproliferative action of the retinoblastoma tumor suppressor protein, RB, is disrupted in the...
It is becoming evident that defective cell cycle regulation is an important property of the cancer c...
It is widely accepted that phosphorylation of the retinoblastoma (Rb) protein during the G1 phase of...
Background: The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein P...
The ability to regulate cell cycle progression is one of the differences that separates normal from ...
The retinoblastoma tumor suppressor protein (RB) is activated/dephosphorylated to mediate cell cycle...