AbstractThe Wistar rat is a commonly used strain for experimental animal models. Recently it was shown that results vary between studies using Wistar rats of different suppliers. Therefore we studied whether Wistar rats obtained from Harlan Laboratories (Ha, n=24) and Charles River (CR, n=22) had a different outcome in an acute myocardial infarction (AMI) model. AMI was induced in both Ha and CR Wistar rats by one operator. This resulted in a significantly higher survival rate for Ha (79.2±10.2%) compared with CR rats (54.2±10.2%, p<0.05). Furthermore, CR rats had lost significantly more weight after 7days (−5.9±3.1%) compared with Ha rats (−0.8±1.7%; p<0.001), indicating a worse health status of the CR rats. Paradoxically, the induced infa...
In most pre-clinical animal studies investigating stem cell therapy in acute myocardial infarction (...
Objectives: Chronic renal dysfunction severely increases cardiovascular risk. Adverse cardiac remode...
Severe myocardial necrosis was produced in virgin Sprague-Dawley rats without preexisting arterioscl...
AbstractThe Wistar rat is a commonly used strain for experimental animal models. Recently it was sho...
Background and Aim: Several difficulties are involved in creating models for myocardial infarction (...
Two-vessel occlusion, a frequently used model of global cerebral ischemia. in rats, results in a dys...
The most common rat model of myocardial infarction (MI) is by ligation of left anterior descending (...
This chapter will discuss the variability in infarct size after ischaemic stroke in rat models of st...
There are several experimental models for the in vivo investigation of myocardial infarction (MI) in...
Background and Aim: Several difficulties are involved in creating models for myocardial infarction (...
Objective: To perform a comparative assessment of two surgical techniques that are used creating an ...
Major depression is associated with medical comorbidity such as ischaemic heart disease and diabetes...
Analysis separately for each groups There was no statistical difference in LVEF, LVES, and LVED para...
Myocardial infarction (MI) was induced in rats by coronary ligation to compare changes in vascular r...
Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. Thi...
In most pre-clinical animal studies investigating stem cell therapy in acute myocardial infarction (...
Objectives: Chronic renal dysfunction severely increases cardiovascular risk. Adverse cardiac remode...
Severe myocardial necrosis was produced in virgin Sprague-Dawley rats without preexisting arterioscl...
AbstractThe Wistar rat is a commonly used strain for experimental animal models. Recently it was sho...
Background and Aim: Several difficulties are involved in creating models for myocardial infarction (...
Two-vessel occlusion, a frequently used model of global cerebral ischemia. in rats, results in a dys...
The most common rat model of myocardial infarction (MI) is by ligation of left anterior descending (...
This chapter will discuss the variability in infarct size after ischaemic stroke in rat models of st...
There are several experimental models for the in vivo investigation of myocardial infarction (MI) in...
Background and Aim: Several difficulties are involved in creating models for myocardial infarction (...
Objective: To perform a comparative assessment of two surgical techniques that are used creating an ...
Major depression is associated with medical comorbidity such as ischaemic heart disease and diabetes...
Analysis separately for each groups There was no statistical difference in LVEF, LVES, and LVED para...
Myocardial infarction (MI) was induced in rats by coronary ligation to compare changes in vascular r...
Investigating focal cerebral ischaemia requires animal models that are relevant to human stroke. Thi...
In most pre-clinical animal studies investigating stem cell therapy in acute myocardial infarction (...
Objectives: Chronic renal dysfunction severely increases cardiovascular risk. Adverse cardiac remode...
Severe myocardial necrosis was produced in virgin Sprague-Dawley rats without preexisting arterioscl...