AbstractDiastolic dysfunction is characterized by slow or incomplete relaxation of the ventricles during diastole, and is an important contributor to heart failure pathophysiology. Clinical symptoms include fatigue, shortness of breath, and pulmonary and peripheral edema, all contributing to decreased quality of life and poor prognosis. There are currently no therapies available that directly target the heart pump defects in diastolic function. Calcium mishandling is a hallmark of heart disease and has been the subject of a large body of research. Efforts are ongoing in a number of gene therapy approaches to normalize the function of calcium handling proteins such as sarcoplasmic reticulum calcium ATPase. An alternative approach to address ...
Calcium (Ca2+) is the major mediator of cardiac contractile function. It plays a key role in regulat...
Heart failure is a growing major cause of human morbidity and mortality worldwide. A wave of new ins...
Professional Biological Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Rese...
AbstractDiastolic dysfunction is characterized by slow or incomplete relaxation of the ventricles du...
Diastolic heart failure (HF) is associated with significant morbidity and mortality, and is a growin...
This thesis is focused on diastolic dysfunction (DD), a pathological condition characterized by slow...
Defective cardiac muscle relaxation plays a causal role in heart failure. Shown here is the new in v...
Intracellular calcium signaling is a universal language source shared by the most part of biological...
Myocardial relaxation is an energy-dependent process. Indeed, adenosine triphosphate (ATP) is requir...
Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-economic b...
The sole purpose of the heart is to pump blood through the body. In order to achieve this, it is imp...
Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the ...
ii Fatigue and skeletal muscle weakness are problems associated with congestive heart failure. Resea...
Calcium (Ca2+) ions are the currency of heart muscle activity. During excitation-contraction couplin...
BACKGROUND: Ischemia is characterized by an increase in intracellular calcium and occurrence of dias...
Calcium (Ca2+) is the major mediator of cardiac contractile function. It plays a key role in regulat...
Heart failure is a growing major cause of human morbidity and mortality worldwide. A wave of new ins...
Professional Biological Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Rese...
AbstractDiastolic dysfunction is characterized by slow or incomplete relaxation of the ventricles du...
Diastolic heart failure (HF) is associated with significant morbidity and mortality, and is a growin...
This thesis is focused on diastolic dysfunction (DD), a pathological condition characterized by slow...
Defective cardiac muscle relaxation plays a causal role in heart failure. Shown here is the new in v...
Intracellular calcium signaling is a universal language source shared by the most part of biological...
Myocardial relaxation is an energy-dependent process. Indeed, adenosine triphosphate (ATP) is requir...
Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-economic b...
The sole purpose of the heart is to pump blood through the body. In order to achieve this, it is imp...
Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the ...
ii Fatigue and skeletal muscle weakness are problems associated with congestive heart failure. Resea...
Calcium (Ca2+) ions are the currency of heart muscle activity. During excitation-contraction couplin...
BACKGROUND: Ischemia is characterized by an increase in intracellular calcium and occurrence of dias...
Calcium (Ca2+) is the major mediator of cardiac contractile function. It plays a key role in regulat...
Heart failure is a growing major cause of human morbidity and mortality worldwide. A wave of new ins...
Professional Biological Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Rese...