Preparation and cytotoxicity of N,N,N-trimethyl chitosan/alginate beads containing gold nanoparticles
- Martins, Alessandro F.
- Facchi, Suelen P.
- Monteiro, Johny P.
- Nocchi, Samara R.
- Silva, Cleiser T.P.
- Nakamura, Celso V.
- Girotto, Emerson M.
- Rubira, Adley F.
- Muniz, Edvani C.
DOIAbstract
AbstractPolyelectrolyte complex beads based on N,N,N-trimethyl chitosan (TMC) and sodium alginate (ALG) were obtained. This biomaterial was characterised by FTIR, TGA/DTG, DSC and SEM analysis. The good properties of polyelectrolyte complex hydrogel beads were associated, for the first time, with gold nanoparticles (AuNPs). Through a straightforward methodology, AuNPs were encapsulated into the beads. The in vitro cytotoxicity assays on the Caco-2 colon cancer cells and healthy VERO cells showed that the beads presented good biocompatibility on both cell lines, whereas the beads loaded with gold nanoparticles (beads/AuNPs) was slightly cytotoxic on the Caco-2 and VERO cells
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