AbstractIn voltage-dependent ion channels, pore opening is initiated by electrically driven movements of charged residues, and this movement generates a gating current. To examine structural rearrangements in the Shaker K+ channel, basic residues R365 and R368 in the S4 segment were replaced with histidine, and gating currents were recorded. Changes in gating charge displacement with solvent pH reveal voltage-dependent changes in exposure of the histidine to solvent protons. This technique directly monitors accessibility changes during gating, probes the environment even in confined locations, and introduces minimal interference of gating charge motion. The results indicate that charges 365 and 368 traverse the entire electric field during ...
AbstractWe examined voltage-dependent conformational changes in three specific regions of the Shaker...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
AbstractIn voltage-dependent ion channels, pore opening is initiated by electrically driven movement...
AbstractThe activation of Shaker K+ channels is steeply voltage dependent. To determine whether cons...
© 2018 National Academy of Sciences. All Rights Reserved. The voltage-gated proton (Hv1) channel, a ...
AbstractThe activation of Shaker K+ channels is steeply voltage dependent. To determine whether cons...
AbstractVoltage-activated ion channels respond to changes in membrane voltage by coupling the moveme...
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are compos...
AbstractRecently, the structure of the Shaker channel Kv1.2 has been determined at a 2.9-Å resolutio...
The structural organization of the voltage sensor in K+ channels has been investigated by second sit...
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are compos...
SummaryMembrane depolarization causes voltage-gated ion channels to transition from a resting/closed...
Over two-thirds of a century ago, Hodgkin and Huxley proposed the existence of voltage gated ion cha...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
AbstractWe examined voltage-dependent conformational changes in three specific regions of the Shaker...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
AbstractIn voltage-dependent ion channels, pore opening is initiated by electrically driven movement...
AbstractThe activation of Shaker K+ channels is steeply voltage dependent. To determine whether cons...
© 2018 National Academy of Sciences. All Rights Reserved. The voltage-gated proton (Hv1) channel, a ...
AbstractThe activation of Shaker K+ channels is steeply voltage dependent. To determine whether cons...
AbstractVoltage-activated ion channels respond to changes in membrane voltage by coupling the moveme...
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are compos...
AbstractRecently, the structure of the Shaker channel Kv1.2 has been determined at a 2.9-Å resolutio...
The structural organization of the voltage sensor in K+ channels has been investigated by second sit...
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are compos...
SummaryMembrane depolarization causes voltage-gated ion channels to transition from a resting/closed...
Over two-thirds of a century ago, Hodgkin and Huxley proposed the existence of voltage gated ion cha...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
AbstractWe examined voltage-dependent conformational changes in three specific regions of the Shaker...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlle...