Inositol 1,4,5-trisphosphate and 5′-GTP induce calcium release from different intracellular pools

AbstractIt has been shown recently by several groups that 5′-GTP can release calcium from intracellular compartments independently from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) by a mechanism which seems to be different from that used by Ins(1,4,5)P3. We report here for the first time that the 5′-GTP-sensitive and the Ins(1,4,5)P3-sensitive calcium pools reside in different intracellular compartments