AbstractThis study was designed to evaluate whether glycogen synthase kinase-3β (GSK-3β) inhibitor, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) induced the the expression of connexin 43 (Cx43) to protect against renal ischemia–reperfusion (I/R) injury (RI/RI) in rats. Rats were subjected to 45min ischemia followed 2h reperfusion with TDZD-8 (1mg/kg) for 5min prior to reperfusion. The results indicated that TDZD-8 improved the recovery of renal function, reduced oxidative stress and inflammation injury, and upregulated the expression of (Cx43) as compared to I/R group. Therefore, our study demonstrated that TDZD-8 provided a protection to the kidney against I/R injury in rats through inducing the expression of (Cx43)
Renal disease is a major public health challenge since its prevalence has continuously increased ove...
Abstract Background Ischemia–reperfusion (I/R)-induced acute kidney injury (AKI) not only prolongs t...
Caspase activation has been implicated in the development of ischemia–reperfusion injury. Here, we i...
This study was designed to evaluate whether glycogen synthase kinase-3β (GSK-3β) inhibitor, 4-benzyl...
AbstractThis study was designed to evaluate whether glycogen synthase kinase-3β (GSK-3β) inhibitor, ...
Background/Aims: Diabetes mellitus (DM) can lead to renal damage and dysfunction, and exacerbate ren...
Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important rol...
Renal proximal tubular damage and repair are hallmarks of acute kidney injury. As glycogen synthase ...
The adverse effect of cisplatin administration causes acute kidney injury (AKI) following renal infl...
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by ...
International audienceExcessive recruitment of monocytes and progression of fibrosis are hallmarks o...
International audienceChronic kidney disease is an incurable to date pathology with a continuously g...
© 2015 Wolters Kluwer Health, Inc. All rights reserved. Background. Renal ischemia-reperfusion (I/R)...
International audienceGN refers to a variety of renal pathologies that often progress to ESRD, but t...
Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by m...
Renal disease is a major public health challenge since its prevalence has continuously increased ove...
Abstract Background Ischemia–reperfusion (I/R)-induced acute kidney injury (AKI) not only prolongs t...
Caspase activation has been implicated in the development of ischemia–reperfusion injury. Here, we i...
This study was designed to evaluate whether glycogen synthase kinase-3β (GSK-3β) inhibitor, 4-benzyl...
AbstractThis study was designed to evaluate whether glycogen synthase kinase-3β (GSK-3β) inhibitor, ...
Background/Aims: Diabetes mellitus (DM) can lead to renal damage and dysfunction, and exacerbate ren...
Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important rol...
Renal proximal tubular damage and repair are hallmarks of acute kidney injury. As glycogen synthase ...
The adverse effect of cisplatin administration causes acute kidney injury (AKI) following renal infl...
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by ...
International audienceExcessive recruitment of monocytes and progression of fibrosis are hallmarks o...
International audienceChronic kidney disease is an incurable to date pathology with a continuously g...
© 2015 Wolters Kluwer Health, Inc. All rights reserved. Background. Renal ischemia-reperfusion (I/R)...
International audienceGN refers to a variety of renal pathologies that often progress to ESRD, but t...
Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by m...
Renal disease is a major public health challenge since its prevalence has continuously increased ove...
Abstract Background Ischemia–reperfusion (I/R)-induced acute kidney injury (AKI) not only prolongs t...
Caspase activation has been implicated in the development of ischemia–reperfusion injury. Here, we i...