AbstractTDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia, and mutations in the gene encoding TDP43 cause both disorders, further highlighting its role in disease pathogenesis. TDP43 is a heterogenous ribonucleoprotein, therefore suggesting that alterations in RNA metabolism play a role in these disorders, although direct evidence in patients is lacking. Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy occurring in adults aged older than 50 years and abnormal cytoplasmic accumulations of TDP43 have been consistently described in sIBM myofibers. Here, we exploit high quality RNA from frozen sIBM muscle biopsies for transcriptomic...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
AbstractDiagnostic biomarkers for amyotrophic lateral sclerosis (ALS) have yet to be identified. One...
TDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sc...
AbstractTDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic la...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
ABSTRACT: The nucleic acid binding protein TDP-43 was recently identified in normal myonuclei and in...
TAR DNA binding protein-43 (TDP-43) is found in ubiquitinated inclusions (UBIs) in some frontotempor...
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the commonest motor neuron...
Myotonic dystrophies (DMs) have highly variable clinical manifestations consisting in muscle weaknes...
In this review, we present our most recent understanding of key biomolecular processes that underlie...
It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processin...
AbstractSporadic inclusion-body myositis (s-IBM) is the most common degenerative muscle disease in w...
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism of...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
AbstractDiagnostic biomarkers for amyotrophic lateral sclerosis (ALS) have yet to be identified. One...
TDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sc...
AbstractTDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic la...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of a...
ABSTRACT: The nucleic acid binding protein TDP-43 was recently identified in normal myonuclei and in...
TAR DNA binding protein-43 (TDP-43) is found in ubiquitinated inclusions (UBIs) in some frontotempor...
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the commonest motor neuron...
Myotonic dystrophies (DMs) have highly variable clinical manifestations consisting in muscle weaknes...
In this review, we present our most recent understanding of key biomolecular processes that underlie...
It has been shown that many hereditary motor neuron diseases are caused by mutation of RNA processin...
AbstractSporadic inclusion-body myositis (s-IBM) is the most common degenerative muscle disease in w...
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism of...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
Myotonic dystrophy is a dominantly inherited clinically variable multisystemic disorder, and has bee...
AbstractDiagnostic biomarkers for amyotrophic lateral sclerosis (ALS) have yet to be identified. One...