AbstractSeveral new N1-substituted uncommon purine nucleosides, including doridosine (1-methyl-isoguanosine; m-iG), 1-allyl-isoguanosine (a-iG) and 1-allyl-xanthosine (a-X), have been synthesized and tested as agonists for the adenosine receptors. Some have smooth muscle relaxant or negative chronotropic activities. The X-ray crystal structure of these compounds has been determined at atomic resolution in order to understand the structure-activity relationship. The structures were solved by direct methods and refined by full-matrix least-squares refinement procedure. The crystallographic parameters are: a-iG, space group P21, a=10.573 (1) Å, b=21.955 (2) Å, c=14.360 (1) Å, β=110.65 (1)°, no. of 3σ Fo's=4585, R=0.047; a-X, space group P21212...
The preparation and high-resolution 1H NMR conformational analysis of the two novel nucleoside analo...
A number of ligands for the adenosine binding sites has been obtained by using nucleoside convergent...
Over the last few years many efforts have been devoted to the discovery of new adenosine antagonists...
AbstractSeveral new N1-substituted uncommon purine nucleosides, including doridosine (1-methyl-isogu...
[[sponsorship]]分子生物研究所[[note]]已出版;[SCI];沒有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...
The structures of two adenosine receptor ligands were determined from single-crystal X-ray diffracti...
Purines are one of the most ubiquitous heterocyclic ring systems in nature and consequently, they ar...
<div><p>We studied patterns of off-target receptor interactions, mostly at G protein-coupled recepto...
The present study explores the C-3' site of the 3-deoxy-3-xylofuranosyl ring of nucleoside analogues...
Adenosine, the natural ligand of P1 receptors, is implicated in the control of many physiological an...
1'-C-Methyl analogues of adenosine and selective adenosine A, receptor agonists, such as N-[(1R)-1-m...
We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCR...
The present study explores the C-3' site of the 3-deoxy-3-xylofuranosyl ring of nucleoside analogues...
The synthesis and biological evaluation of N6, C8-disubstituted derivatives of adenosine as potentia...
Adenosine is a naturally occurring purine nucleoside that has a wide variety of well-documented regu...
The preparation and high-resolution 1H NMR conformational analysis of the two novel nucleoside analo...
A number of ligands for the adenosine binding sites has been obtained by using nucleoside convergent...
Over the last few years many efforts have been devoted to the discovery of new adenosine antagonists...
AbstractSeveral new N1-substituted uncommon purine nucleosides, including doridosine (1-methyl-isogu...
[[sponsorship]]分子生物研究所[[note]]已出版;[SCI];沒有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/G...
The structures of two adenosine receptor ligands were determined from single-crystal X-ray diffracti...
Purines are one of the most ubiquitous heterocyclic ring systems in nature and consequently, they ar...
<div><p>We studied patterns of off-target receptor interactions, mostly at G protein-coupled recepto...
The present study explores the C-3' site of the 3-deoxy-3-xylofuranosyl ring of nucleoside analogues...
Adenosine, the natural ligand of P1 receptors, is implicated in the control of many physiological an...
1'-C-Methyl analogues of adenosine and selective adenosine A, receptor agonists, such as N-[(1R)-1-m...
We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCR...
The present study explores the C-3' site of the 3-deoxy-3-xylofuranosyl ring of nucleoside analogues...
The synthesis and biological evaluation of N6, C8-disubstituted derivatives of adenosine as potentia...
Adenosine is a naturally occurring purine nucleoside that has a wide variety of well-documented regu...
The preparation and high-resolution 1H NMR conformational analysis of the two novel nucleoside analo...
A number of ligands for the adenosine binding sites has been obtained by using nucleoside convergent...
Over the last few years many efforts have been devoted to the discovery of new adenosine antagonists...