AbstractThe cellular response to DNA damage is coordinated by the p53 protein. Mdm2, an oncoprotein, inhibits p53 and promotes p53 degradation. A recent high-resolution structure of the Mdm2-p53 complex may aid the design of small molecules to disrupt this interaction, for use in investigating the interaction further and for designing anticancer drugs
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 co...
The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is ...
Reactivation of p53 by release of the functional protein from its inhibition by MDM2 provides an eff...
The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects divers...
The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects divers...
It is widely accepted that the MDM2 oncoprotein is an inhibitor of the p53 tumor suppressor, via the...
p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation a...
MDM2 oncogenic protein is the principal cellular antagonist of the p53 tumor suppresser gene. p53 ac...
The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising drug target ...
The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially...
In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of c...
Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often t...
Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately ha...
Murine double minute-2 (MDM2) was first described as a p53-associated protein and potential oncogene...
AbstractThe tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquit...
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 co...
The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is ...
Reactivation of p53 by release of the functional protein from its inhibition by MDM2 provides an eff...
The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects divers...
The p53 tumor suppressor protein is a DNA damage responsive transcription factor that affects divers...
It is widely accepted that the MDM2 oncoprotein is an inhibitor of the p53 tumor suppressor, via the...
p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation a...
MDM2 oncogenic protein is the principal cellular antagonist of the p53 tumor suppresser gene. p53 ac...
The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising drug target ...
The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially...
In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of c...
Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often t...
Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately ha...
Murine double minute-2 (MDM2) was first described as a p53-associated protein and potential oncogene...
AbstractThe tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquit...
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 co...
The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is ...
Reactivation of p53 by release of the functional protein from its inhibition by MDM2 provides an eff...
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