The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes
- Monostory, Katalin
- Kőhalmy, Krisztina
- Prough, Russell A.
- Kóbori, László
- Vereczkey, László
Publication date
January 2005
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractGlucocorticoids act synergistically with polycyclic aromatic hydrocarbons in increasing mRNA and protein levels of CYP1A1 in rat liver. The action of dexamethasone to modify CYP1A1 expression has been investigated in adult human hepatocytes. The effect of dexamethasone on the induction of CYP1A1 by 3-methylcholanthrene is different in rat and human liver cells. Dexamethasone potentiates the induction of CYP1A1 about 3- to 4-fold in rat cells. In human hepatocytes, it reduces CYP1A1 induction by 50–60% at enzyme protein level, while it does not have an effect on CYP1A1 mRNA amount
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