AbstractPremature ageing, one of the characteristics of Down syndrome (DS), may involve oxidative stress and impairment of proteasome activity. Transgenic mice overexpressing the human copper/zinc superoxide dismutase (SOD1) gene are one of the first murine models for DS and it has been shown that SOD1 overexpression might be either deleterious or beneficial. Here, we show a reduction in proteasome activities in the cortex of SOD1 transgenic mice and an associated increase in the content of oxidized SOD1 protein. As we demonstrate that in vitro oxidized SOD can inhibit purified proteasome peptidase activities, modified SOD1 might be partially responsible for proteasome inhibition shown in SOD1 transgenic mice
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
Diverse ‘-omics’ technologies permit the comprehensive quantitative profiling of a variety of biolog...
AbstractPremature ageing, one of the characteristics of Down syndrome (DS), may involve oxidative st...
Mutations in SOD1 cause selective motor neuron degeneration in familial amyotrophic lateral sclerosi...
Mutations in SOD1 cause selective motor neuron degeneration in familial amyotrophic lateral sclerosi...
Amyotrophic lateral sclerosis is a neurodegenerative disease caused by motoneuron loss. Some familia...
Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, w...
We report that the expression of mutant G93A copper/zinc superoxide dismutase (SOD1), associated wit...
Oxidative stress has been implicated as a cause of various diseases such as anaemia. We found that t...
AbstractDown Syndrome is the most common chromosomal disease and is also known for its decreased inc...
<p>A. Western blot of WT and mutant SOD1 proteins run on a SDS gel. The antibody detects both the en...
Several studies support the implication of oxidative stress (OS) in phenotypical alterations of Down...
Approximately 10 % of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and 25 % of FAL...
AbstractIndividuals with Down syndrome (DS) have high levels of oxidative stress throughout the life...
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
Diverse ‘-omics’ technologies permit the comprehensive quantitative profiling of a variety of biolog...
AbstractPremature ageing, one of the characteristics of Down syndrome (DS), may involve oxidative st...
Mutations in SOD1 cause selective motor neuron degeneration in familial amyotrophic lateral sclerosi...
Mutations in SOD1 cause selective motor neuron degeneration in familial amyotrophic lateral sclerosi...
Amyotrophic lateral sclerosis is a neurodegenerative disease caused by motoneuron loss. Some familia...
Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, w...
We report that the expression of mutant G93A copper/zinc superoxide dismutase (SOD1), associated wit...
Oxidative stress has been implicated as a cause of various diseases such as anaemia. We found that t...
AbstractDown Syndrome is the most common chromosomal disease and is also known for its decreased inc...
<p>A. Western blot of WT and mutant SOD1 proteins run on a SDS gel. The antibody detects both the en...
Several studies support the implication of oxidative stress (OS) in phenotypical alterations of Down...
Approximately 10 % of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and 25 % of FAL...
AbstractIndividuals with Down syndrome (DS) have high levels of oxidative stress throughout the life...
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model ...
The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defen...
Diverse ‘-omics’ technologies permit the comprehensive quantitative profiling of a variety of biolog...