Transsynaptic Coordination of Presynaptic and Postsynaptic Modifications underlying Enduring Synaptic Plasticity

Neurexins and neuroligins are cell adhesion molecules that form transsynaptic interactions. In this issue of Neuron, Choi et al. report that neurexin-neuroligin signaling plays a critical role in functional and structural synaptic plasticity underlying memory formation in Aplysia