AbstractThis is the first of a series of papers devoted to lay the foundations of Algebraic Geometry in homotopical and higher categorical contexts. In this first part we investigate a notion of higher topos.For this, we use S-categories (i.e. simplicially enriched categories) as models for certain kind of ∞-categories, and we develop the notions of S-topologies, S-sites and stacks over them. We prove in particular, that for an S-category T endowed with an S-topology, there exists a model category of stacks over T, generalizing the model category structure on simplicial presheaves over a Grothendieck site of Joyal and Jardine. We also prove some analogs of the relations between topologies and localizing subcategories of the categories of pr...