AbstractAntisense strategy requires efficient systems for the delivery of oligodeoxyribonucleotides (ODN) into target cells. Cationic amphiphiles have shown good efficiency in vitro and a lot of attention is currently paid to their interaction with nucleic acids. In the present study, this interaction was, for the first time, analysed at the molecular level, taking advantage of the spectroscopic properties of the positively charged chiral polyene molecule amphotericin B 3-dimethylaminopropyl amide (AMA), the efficiency of which, as delivery system, has been demonstrated [Garcia et al., Pharmacol. Ther. (2000), in press]. By UV-visible absorption and circular dichroism (CD) we studied its self-association properties in pure water, saline and...
As drug candidates, one promising way to improve the cellular delivery efficacy of oligonucleotides ...
Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortu...
The research presented in this thesis is concerned with the linear and nonlinear optical properties ...
AbstractAntisense strategy requires efficient systems for the delivery of oligodeoxyribonucleotides ...
AbstractWe report a study of the behavior of oligodeoxyribonucleotide (ODN)/amphotericin B3-(N′-dime...
There has been great interest recently in therapeutic use of nucleic acids including genes, ribozyme...
Amphotericin B (AmB) is widely used in the treatment of systemic fungal infections, despite its toxi...
In the recent genomic era, a novel gene silencing approach has been introduced based on the use of s...
AbstractAmphotericin B (AmB) is widely used in the treatment of systemic fungal infections, despite ...
Three different ionene polymers with varying quaternary ammonium moieties were used as a proof of co...
Amphotericin B (AmB) is a lifesaving polyene antibiotic used widely to treat deep-seated mycoses. Bo...
International audienceOptical spectroscopic techniques such as CD, Raman scattering, and fluorescenc...
Amphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both t...
Oligonucleotides, short nucleic acids of ≈ 100 bases and under, are therapeutics of great interest b...
AbstractNanodisks (ND) are discrete nanometer scale phospholipid bilayers whose perimeter is circums...
As drug candidates, one promising way to improve the cellular delivery efficacy of oligonucleotides ...
Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortu...
The research presented in this thesis is concerned with the linear and nonlinear optical properties ...
AbstractAntisense strategy requires efficient systems for the delivery of oligodeoxyribonucleotides ...
AbstractWe report a study of the behavior of oligodeoxyribonucleotide (ODN)/amphotericin B3-(N′-dime...
There has been great interest recently in therapeutic use of nucleic acids including genes, ribozyme...
Amphotericin B (AmB) is widely used in the treatment of systemic fungal infections, despite its toxi...
In the recent genomic era, a novel gene silencing approach has been introduced based on the use of s...
AbstractAmphotericin B (AmB) is widely used in the treatment of systemic fungal infections, despite ...
Three different ionene polymers with varying quaternary ammonium moieties were used as a proof of co...
Amphotericin B (AmB) is a lifesaving polyene antibiotic used widely to treat deep-seated mycoses. Bo...
International audienceOptical spectroscopic techniques such as CD, Raman scattering, and fluorescenc...
Amphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both t...
Oligonucleotides, short nucleic acids of ≈ 100 bases and under, are therapeutics of great interest b...
AbstractNanodisks (ND) are discrete nanometer scale phospholipid bilayers whose perimeter is circums...
As drug candidates, one promising way to improve the cellular delivery efficacy of oligonucleotides ...
Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortu...
The research presented in this thesis is concerned with the linear and nonlinear optical properties ...