Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling
AbstractMice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resist...
The prevalence of obesity and diabetes are increasing at alarming rates. Both are major health conce...
Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic lept...
Leptin plays a central role in weight control by suppressing food intake and increasing energy expen...
Obesity is typically associated with resistance to leptin, yet the mechanism by which leptin signali...
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of "leptin...
AbstractCommon obesity is primarily characterized by resistance to the actions of the hormone leptin...
SummaryIn obesity, anorectic responses to leptin are diminished, giving rise to the concept of “lept...
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resi...
Understanding how body weight is regulated at the molecular level is essential for treating obesity....
AbstractIndirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that ...
The prevalence of obesity, and the human and economic costs of the disease, creates a need for bette...
SummaryMolecular-level understanding of body weight control is essential for combating obesity. We s...
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention...
Upon leptin binding, the leptin receptor is activated, leading to stimulation of the JAK/STAT signal...
AbstractMice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resist...
The prevalence of obesity and diabetes are increasing at alarming rates. Both are major health conce...
Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic lept...
Leptin plays a central role in weight control by suppressing food intake and increasing energy expen...
Obesity is typically associated with resistance to leptin, yet the mechanism by which leptin signali...
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of "leptin...
AbstractCommon obesity is primarily characterized by resistance to the actions of the hormone leptin...
SummaryIn obesity, anorectic responses to leptin are diminished, giving rise to the concept of “lept...
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resi...
Understanding how body weight is regulated at the molecular level is essential for treating obesity....
AbstractIndirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that ...
The prevalence of obesity, and the human and economic costs of the disease, creates a need for bette...
SummaryMolecular-level understanding of body weight control is essential for combating obesity. We s...
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention...
Upon leptin binding, the leptin receptor is activated, leading to stimulation of the JAK/STAT signal...
AbstractMice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resist...
The prevalence of obesity and diabetes are increasing at alarming rates. Both are major health conce...
Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic lept...
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