AbstractObjectiveLate saphenous vein graft failure after coronary artery bypass graft surgery is initiated by medial thickening and neointima formation, both of which are mediated by the proliferation of vascular smooth muscle cells. Because porcine vein grafts contain high levels of endothelin 1 receptor subtypes and endothelin 1 promotes the proliferation of vascular smooth muscle cells, the effect of administration of the endothelin 1A receptor antagonist BSF 302146 ([+]-[S]-2-[4,6-dimethyl-pyrimidin-2-yloxy]-3,3-diphenyl-butanoic acid) on porcine vein graft thickening was investigated.MethodsSaphenous vein–carotid artery interposition grafting was performed in 4 groups of large white pigs (30-35 kg, n = 10 for each group). BSF 302146 wa...
ObjectivesThe development of neointimal hyperplasia with subsequent atherosclerotic deposition has b...
Background and purpose: Endothelin-1 mediates its effects on blood pressure and vascular remodellin...
Background: The patency of arteriovenous (AV) polytetrafluoroethylene grafts for hemodialysis is imp...
AbstractObjectiveLate saphenous vein graft failure after coronary artery bypass graft surgery is ini...
AbstractObjective: Although a number of pharmacologic agents have been shown to reduce intimal hyper...
The saphenous vein is the most commonly used bypass graft in patients with coronary artery disease. ...
This thesis looks at clinical and biological aspects of vein graft stenoses in order to improve on e...
AbstractThe long-term clinical success of coronary artery bypass grafting with autologous saphenous ...
PubMed ID: 16354404Intimal thickening, due to smooth muscle cell migration and proliferation, is con...
AbstractPurpose: Endothelin-1 (ET-1) has been implicated in a variety of vascular pathologic conditi...
Background: Bypass grafting remains the standard of care for coronary artery disease and severe lowe...
AbstractBackground: Reducing neointima formation and atherosclerosis are key goals in preventing lat...
ObjectiveIntimal hyperplasia and surface thrombogenicity are major factors in the high failure rate ...
BackgroundRho kinase plays an important role in vascular smooth muscle cell (VSMC) contraction and o...
AIM: To determine the role of endothelium-derived contracting factor (EDCF) in the response to endot...
ObjectivesThe development of neointimal hyperplasia with subsequent atherosclerotic deposition has b...
Background and purpose: Endothelin-1 mediates its effects on blood pressure and vascular remodellin...
Background: The patency of arteriovenous (AV) polytetrafluoroethylene grafts for hemodialysis is imp...
AbstractObjectiveLate saphenous vein graft failure after coronary artery bypass graft surgery is ini...
AbstractObjective: Although a number of pharmacologic agents have been shown to reduce intimal hyper...
The saphenous vein is the most commonly used bypass graft in patients with coronary artery disease. ...
This thesis looks at clinical and biological aspects of vein graft stenoses in order to improve on e...
AbstractThe long-term clinical success of coronary artery bypass grafting with autologous saphenous ...
PubMed ID: 16354404Intimal thickening, due to smooth muscle cell migration and proliferation, is con...
AbstractPurpose: Endothelin-1 (ET-1) has been implicated in a variety of vascular pathologic conditi...
Background: Bypass grafting remains the standard of care for coronary artery disease and severe lowe...
AbstractBackground: Reducing neointima formation and atherosclerosis are key goals in preventing lat...
ObjectiveIntimal hyperplasia and surface thrombogenicity are major factors in the high failure rate ...
BackgroundRho kinase plays an important role in vascular smooth muscle cell (VSMC) contraction and o...
AIM: To determine the role of endothelium-derived contracting factor (EDCF) in the response to endot...
ObjectivesThe development of neointimal hyperplasia with subsequent atherosclerotic deposition has b...
Background and purpose: Endothelin-1 mediates its effects on blood pressure and vascular remodellin...
Background: The patency of arteriovenous (AV) polytetrafluoroethylene grafts for hemodialysis is imp...