Localization of the Darier Disease Gene to a 2-cM Portion of 12q23-24.1
- Wakem, P.
- Ikeda, S.
- Haake, A.
- Polakowska, R.
- Ewing, N.
- Sarret, Y.
- Duvic, M.
- Berg, D.
- Bassett, A.
- Kennedy, J.L.
- Tuskis, A.
- Epstein, E.H.
- Goldsmith, L.A.
Publication date
February 1996
DOI Publisher
The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.Abstract
Positional cloning with microsatellite markers allowed further localization of the Darier disease gene to a 2-cM interval of chromosome 12, 12q23-24.1, between the polymorphic loci D12S234 and D12S129. A region this size is suitable for construction of a contig to identify the Darier disease gene. Use of a polymorphic intronic marker for nitric oxide synthetase 1 gene, which maps to the same chromosomal area as the Darier gene, allowed exclusion of that gene as the Darier disease gene
Add to ORKG