AbstractLight-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhodopsin to photoreceptor death are yet unclear. Here, we uncover a pathway by which activation of rhodopsin in Drosophila mediates apoptosis through a G protein–independent mechanism. This process involves the formation of membrane complexes of phosphorylated, activated rhodopsin and its inhibitory protein arrestin, and subsequent clathrin-dependent endocytosis of these complexes into a cytoplasmic compartment. Together, ...
Background: Continuous exposure to light, even at relatively low intensities, leads to retinal damag...
2012-07-25Autosomal dominant retinitis pigmentosa (ADRP) is a blinding disorder whose most frequent ...
Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previo...
AbstractLight-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration...
AbstractAlthough many different mutations in humans and Drosophila cause retinal degeneration, in mo...
SummaryBackground: Arrestins are pivotal, multifunctional organizers of cell responses to GPCR stimu...
AbstractAlthough many different mutations in humans and Drosophila cause retinal degeneration, in mo...
Previously, we have identified a class of retinal degeneration mutants in Drosophila in which the no...
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal t...
AbstractPreviously we have shown that a subset of visual transduction mutants in Drosophila melanoga...
SummaryAlthough apoptosis is mechanistically well understood, a comprehensive understanding of how c...
Although apoptosis is mechanistically well understood, a comprehensive understanding of how cells mo...
Vertebrate and fly rhodopsins are prototypical GPCRs that have served for a long time as model syste...
AbstractBackground: Continuous exposure to light, even at relatively low intensities, leads to retin...
SummaryUpon illumination, visual arrestin translocates from photoreceptor cell bodies to rhodopsin a...
Background: Continuous exposure to light, even at relatively low intensities, leads to retinal damag...
2012-07-25Autosomal dominant retinitis pigmentosa (ADRP) is a blinding disorder whose most frequent ...
Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previo...
AbstractLight-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration...
AbstractAlthough many different mutations in humans and Drosophila cause retinal degeneration, in mo...
SummaryBackground: Arrestins are pivotal, multifunctional organizers of cell responses to GPCR stimu...
AbstractAlthough many different mutations in humans and Drosophila cause retinal degeneration, in mo...
Previously, we have identified a class of retinal degeneration mutants in Drosophila in which the no...
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal t...
AbstractPreviously we have shown that a subset of visual transduction mutants in Drosophila melanoga...
SummaryAlthough apoptosis is mechanistically well understood, a comprehensive understanding of how c...
Although apoptosis is mechanistically well understood, a comprehensive understanding of how cells mo...
Vertebrate and fly rhodopsins are prototypical GPCRs that have served for a long time as model syste...
AbstractBackground: Continuous exposure to light, even at relatively low intensities, leads to retin...
SummaryUpon illumination, visual arrestin translocates from photoreceptor cell bodies to rhodopsin a...
Background: Continuous exposure to light, even at relatively low intensities, leads to retinal damag...
2012-07-25Autosomal dominant retinitis pigmentosa (ADRP) is a blinding disorder whose most frequent ...
Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previo...