AbstractMicroRNAs (miRNAs) are a large family of small regulatory RNAs that are poorly understood. The let-7 miRNA regulates the timing of the developmental switch from larval to adult cell fates during Caenorhabditis elegans development. Expression of let-7 RNA is temporally regulated, with robust expression in the fourth larval and adult stages. Here, we show that, like let-7 RNA, a transcriptional fusion of the let-7 promoter to gfp is temporally regulated, indicating that let-7 is transcriptionally controled. Temporal upregulation of let-7 transcription requires an enhancer element, the temporal regulatory element (TRE), situated about 1200 base pairs upstream of the start of the mature let-7 RNA. The TRE is both necessary and sufficien...
AbstractThe temporal sequence of cell division and differentiation is explicitly controlled for succ...
The let-7 family of miRNAs have been shown to control developmental timing in organisms from C. eleg...
ABSTRACT The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis eleg...
AbstractMicroRNAs (miRNAs) are a large family of small regulatory RNAs that are poorly understood. T...
AbstractThe let-7 microRNA (miRNA) is highly conserved across animal phyla and generally regulates c...
AbstractThe let-7 family of microRNAs (miRNAs) are important regulators of developmental timing and ...
AbstractThe heterochronic pathway controls temporal patterning during Caenorhabditis elegans larval ...
AbstractMicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in ma...
SummaryThe microRNA let-7 is a critical regulator of developmental timing events at the larval-to-ad...
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in many multi...
The let-7 miRNA is a highly conserved regulatory molecule that dictates development across animal ph...
Two small temporal RNAs (stRNAs), lin-4 and let-7, control developmental timing in Caenorhabditis el...
Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first ...
AbstractThe lin-4 and let-7 small temporal RNAs play a central role in controlling the timing of Cae...
SummaryThe C. elegans heterochronic genes program stage-specific temporal identities in multiple tis...
AbstractThe temporal sequence of cell division and differentiation is explicitly controlled for succ...
The let-7 family of miRNAs have been shown to control developmental timing in organisms from C. eleg...
ABSTRACT The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis eleg...
AbstractMicroRNAs (miRNAs) are a large family of small regulatory RNAs that are poorly understood. T...
AbstractThe let-7 microRNA (miRNA) is highly conserved across animal phyla and generally regulates c...
AbstractThe let-7 family of microRNAs (miRNAs) are important regulators of developmental timing and ...
AbstractThe heterochronic pathway controls temporal patterning during Caenorhabditis elegans larval ...
AbstractMicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in ma...
SummaryThe microRNA let-7 is a critical regulator of developmental timing events at the larval-to-ad...
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in many multi...
The let-7 miRNA is a highly conserved regulatory molecule that dictates development across animal ph...
Two small temporal RNAs (stRNAs), lin-4 and let-7, control developmental timing in Caenorhabditis el...
Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first ...
AbstractThe lin-4 and let-7 small temporal RNAs play a central role in controlling the timing of Cae...
SummaryThe C. elegans heterochronic genes program stage-specific temporal identities in multiple tis...
AbstractThe temporal sequence of cell division and differentiation is explicitly controlled for succ...
The let-7 family of miRNAs have been shown to control developmental timing in organisms from C. eleg...
ABSTRACT The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis eleg...