Effects of intravenous ondansetron and granisetron on hemodynamic changes and motor and sensory blockade induced by spinal anesthesia in parturients undergoing cesarean section

AbstractBackgroundSpinal anesthesia has many advantages for cesarean section parturients, but hypotension is considered the most frequent complication and can be managed by different interventions. One of these interventions is to give a serotonin receptor antagonist prior to spinal anesthesia.ObjectivesTo compare between two serotonin receptor antagonists on the hemodynamics, sensory, and motor blockade induced by intrathecal bupivacaine in parturients undergoing cesarean section.Patients and methodsSixty patients undergoing elective cesarean section under spinal anesthesia by intrathecal bupivacaine were randomly divided into three groups (20 pregnant females of ASA I–II physical status in each group). Group O received intravenous 4mg ondansetron diluted in 10ml normal saline and injected over 1min, 5min before spinal anesthesia, group G given intravenous 1mg granisetron by the same route and group S given 10ml normal saline. Mean arterial blood pressure, heart rate, vasopressor use, sensory, and motor blockade were assessed.ResultsDecreases in mean arterial pressure were significantly lower in group O than groups G and S with lower vasopressor use (P<0.05), while there was significant faster sensory recovery in group G than groups O and S (P