Expression and Clinicopathology of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinomas

AbstractHeat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma. The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry. HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3%) and in 30 of 120 mucous membranes adjacent to cancers (25.0%). Gp96 detected in esophageal squamous cell carcinoma and in mucous membrane adjacent to cancer was 85.0% and 20.0% respectively. Both HSP72 and gp96 mainly stained in cytoplasm. HSP72 and gp96 expression in esophageal squamous cell carcinomas with metastasis was significantly higher than those with non-metastasis (P