AbstractIntrons are flanked by a partially conserved coding sequence that forms the immediate exon junction sequence following intron removal from pre-mRNA. Phylogenetic evidence indicates that these sequences have been targeted by numerous intron insertions during evolution, but little is known about this process. Here, we test the prediction that exon junction sequences were functional splice sites that existed in the coding sequence of genes prior to the insertion of introns. To do this, we experimentally identified nine cryptic splice sites within the coding sequence of actin genes from humans, Arabidopsis, and Physarum by inactivating their normal intron splice sites. We found that seven of these cryptic splice sites correspond exactly...
AbstractAnalysis of the exon–intron structures of 2208 human genes has revealed that there is a stat...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2006.This electronic v...
AbstractIntrons are flanked by a partially conserved coding sequence that forms the immediate exon j...
AbstractMost of the eukaryotic protein-coding genes are interrupted by multiple introns. A substanti...
AbstractThe evolutionary origin of spliceosomal introns remains elusive. The startling success of a ...
AbstractA catalogue of intron positions obtained from a large number of actin genes has been compile...
AbstractA comparison of the nucleotide sequences around the splice junctions that flank old (shared ...
AbstractA comparison of the nucleotide sequences around the splice junctions that flank old (shared ...
AbstractMost of the eukaryotic protein-coding genes are interrupted by multiple introns. A substanti...
AbstractThe evolutionary origin of spliceosomal introns remains elusive. The startling success of a ...
Background: Variations in transcript splicing can reveal how eukaryotes recognize intronic splice si...
Over 30 years since their discovery, the origin of spliceosomal introns remains uncertain. One nearl...
AbstractA catalogue of intron positions obtained from a large number of actin genes has been compile...
Over 30 years since their discovery, the origin of spliceosomal introns remains uncertain. One nearl...
AbstractAnalysis of the exon–intron structures of 2208 human genes has revealed that there is a stat...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2006.This electronic v...
AbstractIntrons are flanked by a partially conserved coding sequence that forms the immediate exon j...
AbstractMost of the eukaryotic protein-coding genes are interrupted by multiple introns. A substanti...
AbstractThe evolutionary origin of spliceosomal introns remains elusive. The startling success of a ...
AbstractA catalogue of intron positions obtained from a large number of actin genes has been compile...
AbstractA comparison of the nucleotide sequences around the splice junctions that flank old (shared ...
AbstractA comparison of the nucleotide sequences around the splice junctions that flank old (shared ...
AbstractMost of the eukaryotic protein-coding genes are interrupted by multiple introns. A substanti...
AbstractThe evolutionary origin of spliceosomal introns remains elusive. The startling success of a ...
Background: Variations in transcript splicing can reveal how eukaryotes recognize intronic splice si...
Over 30 years since their discovery, the origin of spliceosomal introns remains uncertain. One nearl...
AbstractA catalogue of intron positions obtained from a large number of actin genes has been compile...
Over 30 years since their discovery, the origin of spliceosomal introns remains uncertain. One nearl...
AbstractAnalysis of the exon–intron structures of 2208 human genes has revealed that there is a stat...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2006.This electronic v...