During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A n...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell...
SummaryRecent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress con...
OBJECTIVE—In diabetes, glucose toxicity affects different or-gan systems, including pancreatic islet...
SummaryWhen unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulu...
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
has been linked to cell apoptosis and inflammation in a number of diseases, including type 2 diabete...
The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome acti...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is ...
Chronic hyperglycemia is a known risk factor in type 1 diabetes (T1D) including pancreatic beta, ren...
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A n...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell...
SummaryRecent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress con...
OBJECTIVE—In diabetes, glucose toxicity affects different or-gan systems, including pancreatic islet...
SummaryWhen unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulu...
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
has been linked to cell apoptosis and inflammation in a number of diseases, including type 2 diabete...
The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome acti...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it ...
Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is ...
Chronic hyperglycemia is a known risk factor in type 1 diabetes (T1D) including pancreatic beta, ren...
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A n...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a centra...
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