Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol alpha 1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K
Cottaz, S
Brimacombe, J S
Ferguson, M A J

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

Ralton, Julie E.
Milne, Kenneth
Güther, Maria Lucia S.
Field, Robert A.
Ferguson, Michael A. J,

January 1993

The inhibition of glycosylphosphatidylinositol anchor biosynthesis by mannosamine has been described...

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol α1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K.
Cottaz, Sylvain
Brimacombe, John S.
Ferguson, Michael A. J.

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Borissow, Charles N.
Smith, Terry K.
Ferguson, Michael A. J.
Brimacombe, John S.

January 2001

Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested a...

Parasite glycoconjugates. Part 3:synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Cottaz, Sylvain
Brimacombe, John S.
Ferguson, Michael A. J.

January 1995

Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn...

Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

Urbaniak, Michael D.
Crossman, Arthur
Ferguson, Michael A. J.

August 2008

Glycosylphosphatidylinositol precursor-analogues were synthesized in which the natural diacylglycero...

Parasite glycoconjugates:Part 7. Synthesis of further substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

September 1997

Substrate analogues of 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-[sn-2,3-bis(my...

Parasite-specific inhibition of the glycosylphosphatidylinositol biosynthetic pathway by stereoisomeric substrate analogues

Smith, Terry K.
Paterson, Michael J.
Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

September 2000

The natural substrate for the first alpha-D-mannosyltransferase of glycosylphosphatidylinositol bios...

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness

Smith, Terry K
Young, Benjamin L.
Denton, Helen
Hughes, David L.
Wagner, Gerd K.

March 2009

Drug-like molecules with activity against Trypanosoma brucei are urgently required as potential ther...

Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues

Michael D. Urbaniak (166658)
Dmitry V. Yashunsky (1265466)
Arthur Crossman (1265469)
Andrei V. Nikolaev (1265463)
Michael A. J. Ferguson (166662)

December 2015

Glycosylphosphatidylinositol (GPI)-anchored proteins are abundant in the protozoan parasite Trypa...

The synthesis of some deoxygenated analogues of early intermediates in the biosynthesis of glycosylphosphatidylinositol (GPI) membrane anchors

Dix, Alexander P.
Borissow, Charles N.
Ferguson, Michael A. J.
Brimacombe, John S.

January 2004

Syntheses are described of 2-azido-4,6-di-O-benzyl-2,3-dideoxy-D-ribo-hexopyranosyl fluoride, 6-O-ac...

Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in trypanosoma brucei and HeLa cells

Smith, Terry K.
Crossman, Arthur
Paterson, Michael J.
Borissow, Charles N.
Brimacombe, John S.
Ferguson, Michael A. J.

October 2002

A series of synthetic analogues Of D-GlcNalpha1-6-D-myo-inositol-1-HPO4-sn-1,2-dipalmitoylglycerol, ...

Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Smith, Terry K.
Sharma, Deepak K.
Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

November 1999

Synthetic analogues of D-GlcN alpha 1-6D-myo-inositol-1-HPO4-3(sn-1,2-diacylglycerol) (GlcN-PI), wit...

Synthesis of some second-generation substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Crossman Jr., Arthur
Brimacombe, John S.
Ferguson, Michael A. J.
Smith, Terry K.

September 1999

1-D-6-O-(2-Amino-2-deoxy-alpha-D-glucopyranosyl)-2-O-octyl-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-...

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol alpha 1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K
Cottaz, S
Brimacombe, J S
Ferguson, M A J

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

Ralton, Julie E.
Milne, Kenneth
Güther, Maria Lucia S.
Field, Robert A.
Ferguson, Michael A. J,

January 1993

The inhibition of glycosylphosphatidylinositol anchor biosynthesis by mannosamine has been described...

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol α1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K.
Cottaz, Sylvain
Brimacombe, John S.
Ferguson, Michael A. J.

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Borissow, Charles N.
Smith, Terry K.
Ferguson, Michael A. J.
Brimacombe, John S.

January 2001

Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested a...

Parasite glycoconjugates. Part 3:synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Cottaz, Sylvain
Brimacombe, John S.
Ferguson, Michael A. J.

January 1995

Substrate analogues of sodium 1D-6-O-(2-[H] acetamido-2-deoxy-a-D-glucopyranosyl)-myo-inositol 1-[sn...

Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

Urbaniak, Michael D.
Crossman, Arthur
Ferguson, Michael A. J.

August 2008

Glycosylphosphatidylinositol precursor-analogues were synthesized in which the natural diacylglycero...

Parasite glycoconjugates:Part 7. Synthesis of further substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

September 1997

Substrate analogues of 1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-[sn-2,3-bis(my...

Parasite-specific inhibition of the glycosylphosphatidylinositol biosynthetic pathway by stereoisomeric substrate analogues

Smith, Terry K.
Paterson, Michael J.
Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

September 2000

The natural substrate for the first alpha-D-mannosyltransferase of glycosylphosphatidylinositol bios...

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness

Smith, Terry K
Young, Benjamin L.
Denton, Helen
Hughes, David L.
Wagner, Gerd K.

March 2009

Drug-like molecules with activity against Trypanosoma brucei are urgently required as potential ther...

Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues

Michael D. Urbaniak (166658)
Dmitry V. Yashunsky (1265466)
Arthur Crossman (1265469)
Andrei V. Nikolaev (1265463)
Michael A. J. Ferguson (166662)

December 2015

Glycosylphosphatidylinositol (GPI)-anchored proteins are abundant in the protozoan parasite Trypa...

The synthesis of some deoxygenated analogues of early intermediates in the biosynthesis of glycosylphosphatidylinositol (GPI) membrane anchors

Dix, Alexander P.
Borissow, Charles N.
Ferguson, Michael A. J.
Brimacombe, John S.

January 2004

Syntheses are described of 2-azido-4,6-di-O-benzyl-2,3-dideoxy-D-ribo-hexopyranosyl fluoride, 6-O-ac...

Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in trypanosoma brucei and HeLa cells

Smith, Terry K.
Crossman, Arthur
Paterson, Michael J.
Borissow, Charles N.
Brimacombe, John S.
Ferguson, Michael A. J.

October 2002

A series of synthetic analogues Of D-GlcNalpha1-6-D-myo-inositol-1-HPO4-sn-1,2-dipalmitoylglycerol, ...

Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei

Smith, Terry K.
Sharma, Deepak K.
Crossman, Arthur
Brimacombe, John S.
Ferguson, Michael A. J.

November 1999

Synthetic analogues of D-GlcN alpha 1-6D-myo-inositol-1-HPO4-3(sn-1,2-diacylglycerol) (GlcN-PI), wit...

Synthesis of some second-generation substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

Crossman Jr., Arthur
Brimacombe, John S.
Ferguson, Michael A. J.
Smith, Terry K.

September 1999

1-D-6-O-(2-Amino-2-deoxy-alpha-D-glucopyranosyl)-2-O-octyl-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-...

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol alpha 1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K
Cottaz, S
Brimacombe, J S
Ferguson, M A J

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

Ralton, Julie E.
Milne, Kenneth
Güther, Maria Lucia S.
Field, Robert A.
Ferguson, Michael A. J,

January 1993

The inhibition of glycosylphosphatidylinositol anchor biosynthesis by mannosamine has been described...

Substrate specificity of the dolichol phosphate mannose: Glucosaminyl phosphatidylinositol α1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

Smith, Terry K.
Cottaz, Sylvain
Brimacombe, John S.
Ferguson, Michael A. J.

March 1996

The biosynthesis of glycosylphosphatidylinositol (GPI) precursors in Trypanosoma brucei involves the...

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Abstract

Extracted data

Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Abstract

Extracted data

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