Transcriptional regulation of phosphoenolpyruvate carboxykinase (PEPCK), the rate limiting enzyme in hepatic gluconeogenesis, by insulin was investigated with the use of adenovirus vectors encoding various mutant signaling proteins. Insulin inhibited transcription induced by dexamethasone and cAMP of a chloramphenicol acetyltransferase (CAT) reporter gene fused with the PEPCK promoter sequence in HL1C cells stably transfected with this construct. A dominant negative mutant of phosphoinositide (PI) 3-kinase blocked insulin inhibition of transcription of the PEPCK-CAT fusion gene, whereas a constitutively active mutant of PI 3-kinase mimicked the effect of insulin. Although a constitutively active mutant of Akt (protein kinase B) inhibited PE...
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphata...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...
Transcriptional regulation of phosphoenolpyruvate carboxykinase (PEPCK), the rate limiting enzyme in...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first committed step in hepatic gluconeogene...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first committed step in hepatic gluconeogene...
Expression of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in hepatic gluconeog...
Expression of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in hepatic gluconeog...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate limiting step in hepatic gluconeogenesi...
OBJECTIVE-Abnormal expression of the hepatic gluconeogenic genes (glucose-6-phosphatase [G6Pase] and...
A major action of insulin is to regulate the transcription rate of specific genes. The expression of...
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphata...
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphata...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...
Transcriptional regulation of phosphoenolpyruvate carboxykinase (PEPCK), the rate limiting enzyme in...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first committed step in hepatic gluconeogene...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first committed step in hepatic gluconeogene...
Expression of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in hepatic gluconeog...
Expression of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in hepatic gluconeog...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate limiting step in hepatic gluconeogenesi...
OBJECTIVE-Abnormal expression of the hepatic gluconeogenic genes (glucose-6-phosphatase [G6Pase] and...
A major action of insulin is to regulate the transcription rate of specific genes. The expression of...
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphata...
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphata...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesi...