Background & Aims: Suppression of the hypothalamic-pituitary-adrenal axis occurs in cirrhosis and cholestasis and is associated with increased concentrations of bile acids. We investigated whether this was mediated through bile acids acting to impair steroid clearance by inhibiting glucocorticoid metabolism by 5 beta-reductase.Methods: The effect of bile acids on glucocorticoid metabolism was studied in vitro in hepatic subcellular fractions and hepatoma cells, allowing quantitation of the kinetics and transcript abundance of 5 beta-reductase. Metabolism was subsequently examined in vivo in rats following dietary manipulation or bile duct ligation. Finally, glucocorticoid metabolism was assessed in humans with obstructive jaundice.Resul...
Abstract: Background & Aims: We tested the hypothesis that during bile duct obstruction, increased b...
An increased level of plasma cholesterol is associated with premature development of atherosclerosis...
Bile acids (BA) are amphipathic molecules whosephysicochemical properties facilitate the solu-biliza...
Background & Aims: Suppression of the hypothalamic-pituitary-adrenal axis occurs in cirrhosis an...
Background & AimsSuppression of the hypothalamic–pituitary–adrenal axis occurs in cirrhosis and chol...
Background/Aims: Animal studies implicate a role of bile acids (BA) in thyroid-regulated energy expe...
Introduction: Bile acids are synthesized from cholesterol exclusively in the liver. The rate of bile...
Background & Aims: Glucocorticoids, produced by the adrenal gland under control of the hypothalamic-...
SummarySystemic bile acid (BA) homeostasis is a critical determinant of dietary fat digestion, enter...
Bile acids are not merely soaps to aid lipid absorption but also function as signaling molecules in ...
Introduction: Bile acids are synthesized from cholesterol exclusively in the liver. The rate of bile...
There is an increasing need to explore the mechanism of the progression of non-alcoholic fatty liver...
Renal sodium retention and potassium loss occur early, in many instances in the preascitic state of ...
<div><p>Introduction</p><p>Cholestasis is characterized by accumulation of bile acids and inflammati...
Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major...
Abstract: Background & Aims: We tested the hypothesis that during bile duct obstruction, increased b...
An increased level of plasma cholesterol is associated with premature development of atherosclerosis...
Bile acids (BA) are amphipathic molecules whosephysicochemical properties facilitate the solu-biliza...
Background & Aims: Suppression of the hypothalamic-pituitary-adrenal axis occurs in cirrhosis an...
Background & AimsSuppression of the hypothalamic–pituitary–adrenal axis occurs in cirrhosis and chol...
Background/Aims: Animal studies implicate a role of bile acids (BA) in thyroid-regulated energy expe...
Introduction: Bile acids are synthesized from cholesterol exclusively in the liver. The rate of bile...
Background & Aims: Glucocorticoids, produced by the adrenal gland under control of the hypothalamic-...
SummarySystemic bile acid (BA) homeostasis is a critical determinant of dietary fat digestion, enter...
Bile acids are not merely soaps to aid lipid absorption but also function as signaling molecules in ...
Introduction: Bile acids are synthesized from cholesterol exclusively in the liver. The rate of bile...
There is an increasing need to explore the mechanism of the progression of non-alcoholic fatty liver...
Renal sodium retention and potassium loss occur early, in many instances in the preascitic state of ...
<div><p>Introduction</p><p>Cholestasis is characterized by accumulation of bile acids and inflammati...
Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major...
Abstract: Background & Aims: We tested the hypothesis that during bile duct obstruction, increased b...
An increased level of plasma cholesterol is associated with premature development of atherosclerosis...
Bile acids (BA) are amphipathic molecules whosephysicochemical properties facilitate the solu-biliza...