Add to ORKGRecent genetic findings demonstrate an important role for the epidermal protein filaggrin in the aetiology of atopic diseases, including asthma as well as eczema. Filaggrin is critical to the conversion of keratinocytes to the protein/lipid squames that compose the stratum comeum, the outermost barrier layer of the skin. In 2006, icthyosis vulgaris, a disease characterised by dry, scaly skin, was found to be a semi-dominant Mendelian condition due to mutations at two sites (RSOIX and 2282del4) in the filaggrin gene. An exceptionally strong association has also been shown between these two mutations and the most common distinct form of eczema, atopic dermatitis, in 12 independent European populations, with odds ratios varying between 2.8 and...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
Recent genetic findings demonstrate an important role for the epidermal protein filaggrin in the aet...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
Recent genetic findings demonstrate an important role for the epidermal protein filaggrin in the aet...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The recent identification of loss-of-function mutations in the structural protein filaggrin as a wid...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...
The discovery that null mutations in the filaggrin gene (FLG) are associated with atopic eczema repr...