Add to ORKGNew ferrocenic 4-aminoquinoline urea compounds have been tested for inhibition of trypanothione reductase (TryR) and human glutathione reductase (GR). Several compounds were also tested in vitro against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei rhodesiense. All compounds showed significant improvement in inhibition of TryR relative to chloroquine with the best compound showing an IC50 value of 2.4 mu M (Chloroquine IC50 = 47.6 mu M).</p
High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel che...
Ferroquine (FQ, SSR97193) is a synthetic compound currently in development for the treatment of mala...
<p>A set of aryloxy-quinones, previously synthesized and evaluated against <i>Trypanosoma cruzi</i> ...
New ferrocenic 4-aminoquinoline urea compounds have been tested for inhibition of trypanothione redu...
Trypanothione reductase (TryR) is a key validated enzyme in the trypanothione-based redox metabolism...
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesise...
Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypano...
Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the deve...
There is an urgent need for new drugs for the treatment of tropical parasitic diseases such as human...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used ...
Trypanosomes and Leishmania, the causative agents of African sleeping sickness, Chagas disease, and ...
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesise...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used ...
Trypanothione reductase (TR), an enzyme that buffers oxidative stress in trypanosomatid parasites, w...
High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel che...
Ferroquine (FQ, SSR97193) is a synthetic compound currently in development for the treatment of mala...
<p>A set of aryloxy-quinones, previously synthesized and evaluated against <i>Trypanosoma cruzi</i> ...
New ferrocenic 4-aminoquinoline urea compounds have been tested for inhibition of trypanothione redu...
Trypanothione reductase (TryR) is a key validated enzyme in the trypanothione-based redox metabolism...
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesise...
Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypano...
Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the deve...
There is an urgent need for new drugs for the treatment of tropical parasitic diseases such as human...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used ...
Trypanosomes and Leishmania, the causative agents of African sleeping sickness, Chagas disease, and ...
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesise...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used...
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used ...
Trypanothione reductase (TR), an enzyme that buffers oxidative stress in trypanosomatid parasites, w...
High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel che...
Ferroquine (FQ, SSR97193) is a synthetic compound currently in development for the treatment of mala...
<p>A set of aryloxy-quinones, previously synthesized and evaluated against <i>Trypanosoma cruzi</i> ...