In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification
In mice, three pluripotent stem cell lines have been established from different stage of developing ...
Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types ...
Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell state...
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES...
As it is classically defined, the term stem cell seems at odds with the process of early development...
As it is classically defined, the term stem cell seems at odds with the process of early development...
Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as w...
Embryonic stem cells (ESCs) are a unique tool for genetic perturbation of mammalian cellular and org...
Pluripotency is defined as the ability to develop into all tissues of the adult organism. In vivo, p...
Background: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
BACKGROUND: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
Background: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
Pluripotency is defined as the ability to develop into all tissues of the adult organism. In vivo, p...
textabstractPluripotent stem cell lines can be derived from blastocyst embryos, which yield embryoni...
BACKGROUND:Commitment in embryonic stem cells is often depicted as a binary choice between alternate...
In mice, three pluripotent stem cell lines have been established from different stage of developing ...
Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types ...
Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell state...
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES...
As it is classically defined, the term stem cell seems at odds with the process of early development...
As it is classically defined, the term stem cell seems at odds with the process of early development...
Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as w...
Embryonic stem cells (ESCs) are a unique tool for genetic perturbation of mammalian cellular and org...
Pluripotency is defined as the ability to develop into all tissues of the adult organism. In vivo, p...
Background: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
BACKGROUND: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
Background: Commitment in embryonic stem cells is often depicted as a binary choice between alternat...
Pluripotency is defined as the ability to develop into all tissues of the adult organism. In vivo, p...
textabstractPluripotent stem cell lines can be derived from blastocyst embryos, which yield embryoni...
BACKGROUND:Commitment in embryonic stem cells is often depicted as a binary choice between alternate...
In mice, three pluripotent stem cell lines have been established from different stage of developing ...
Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types ...
Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell state...
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