Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
- Nomura, Toshifumi
- Sandilands, Aileen
- Akiyama, Masashi
- Liao, Haihui
- Evans, Alan T.
- Sakai, Kaori
- Ota, Mitsuhito
- Sugiura, Hisashi
- Yamamoto, Kazuo
- Sato, Hiroshi
- Palmer, Colin N. A.
- Smith, Frances J. D.
- McLean, W. H. Irwin
- Shimizu, Hiroshi
Publication date
January 2007
DOIAbstract
Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD)
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