NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE ABSTRACT IN THE PUBLISHER'S WEBSITE FOR AN ACCURATE DISPLAY. Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (GM/RGL) of protein phosphatase 1 (PP1) causes substantial lowering of the glycogen synthase activity and a 10-fold decrease in the glycogen levels in skeletal muscle. Homozygous GM ?/? mice show increased weight gain after 3 months of age and become obese, weighing ~20% more than their wild-type (WT) littermates after 12 months of age. Glucose tolerance is impaired in 11-month-old GM ?/? mice, and their skeletal muscle is insulin-resistant at =12 months of age. The massive abdominal and other fat depos...
Glycogen is the primary storage form of glucose. Glycogen synthesis and breakdown are tightly contro...
SummaryThe role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of in...
Contains fulltext : 57444.pdf (publisher's version ) (Closed access)Insulinoma-ass...
NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REF...
A prediabetic phenotype of glucose intolerance, insulin resistance and obesity was observed at appro...
Background: Stored glycogen is an important source of energy for skeletal muscle. Human genetic diso...
Objective: Muscle glucose storage and muscle glycogen synthase (gys1) defects have been associated w...
BACKGROUND: Stored glycogen is an important source of energy for skeletal muscle. Human genetic diso...
Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear perox...
Objective: The development of skeletal muscle insulin resistance is an early physiological defect, y...
Protein–tyrosine phosphatase (PTP)1B is a negative regu-lator of insulin signaling and a therapeutic...
© 2016 Dr. Chrysovalantou (Chrisa) Eleni XirouchakiMuscle glucose storage and muscle glycogen syntha...
International audienceBackground/Aims: Myostatin is known as a powerful negative regulator of muscle...
Objective: Increased signal transducer and activator of transcription 3 (STAT3) signaling has been i...
Insulin has been previously shown to regulate the expression of the hepatic glycogen-targeting subun...
Glycogen is the primary storage form of glucose. Glycogen synthesis and breakdown are tightly contro...
SummaryThe role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of in...
Contains fulltext : 57444.pdf (publisher's version ) (Closed access)Insulinoma-ass...
NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REF...
A prediabetic phenotype of glucose intolerance, insulin resistance and obesity was observed at appro...
Background: Stored glycogen is an important source of energy for skeletal muscle. Human genetic diso...
Objective: Muscle glucose storage and muscle glycogen synthase (gys1) defects have been associated w...
BACKGROUND: Stored glycogen is an important source of energy for skeletal muscle. Human genetic diso...
Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear perox...
Objective: The development of skeletal muscle insulin resistance is an early physiological defect, y...
Protein–tyrosine phosphatase (PTP)1B is a negative regu-lator of insulin signaling and a therapeutic...
© 2016 Dr. Chrysovalantou (Chrisa) Eleni XirouchakiMuscle glucose storage and muscle glycogen syntha...
International audienceBackground/Aims: Myostatin is known as a powerful negative regulator of muscle...
Objective: Increased signal transducer and activator of transcription 3 (STAT3) signaling has been i...
Insulin has been previously shown to regulate the expression of the hepatic glycogen-targeting subun...
Glycogen is the primary storage form of glucose. Glycogen synthesis and breakdown are tightly contro...
SummaryThe role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of in...
Contains fulltext : 57444.pdf (publisher's version ) (Closed access)Insulinoma-ass...